| 词条 | 2,4,5-Trihydroxyamphetamine |
| 释义 |
| ImageFile = 2,4,5-trihydroxyamphetamine.svg | ImageSize = 200px | ImageAlt = | IUPACName = 5-(2-Aminopropyl)-1,2,4-benzenetriol | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 136706-33-7 | PubChem = | ChemSpiderID = 112205 | SMILES = CC(N)CC1=C(O)C=C(O)C(O)=C1 | Section2 = {{Chembox Properties | C=9|H=13|N=1|O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} 2,4,5-Trihydroxyamphetamine (THM) is a neurotoxin and a metabolite of MDMA. It comes from the ring-hydroxylation of 3,4-methylenedioxyamphetamine (MDA). In one paper, it was shown to reduce hippocampal tryptophan hydroxylase activity by 54% after short-term treatment.[1] In another study, it was shown to significantly reduce striatal tyrosine hydroxylase activity.[2] See also
References1. ^{{cite journal |title= Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity.| pmid=8496826 | volume=265 | issue=2 | date=May 1993 | journal=J Pharmacol Exp Ther | pages=813–8}} {{Neurotoxins}}{{DEFAULTSORT:Trihydroxyamphetamine, 2,4,5-}}{{Neurotoxin-stub}}2. ^{{cite journal | journal = J Pharmacol Exp Ther | date = 1993 | volume = 265 | issue = 2 | pages = 813–818 | title = Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5-trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxyls activity |vauthors=Elayan I, Gibb JW, Hanson GR, Lim HK, Foltz RL, Johnson M | pmid= 8496826}} 3 : Neurotoxins|Substituted amphetamines|Recreational drug metabolites |
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