| 词条 | 2,4,5-Trihydroxymethamphetamine |
| 释义 |
| ImageFile = 2,4,5-trihydroxymethamphetamine.svg | ImageSize = 200px | ImageAlt = | IUPACName = 5-[2-(Methylamino)propyl]-1,2,4-benzenetriol | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 136706-32-6 | PubChem = | ChemSpiderID = 19983112 | SMILES = CNC(C)CC1=C(O)C=C(O)C(O)=C1 | Section2 = {{Chembox Properties | C=10|H=15|N=1|O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}2,4,5-Trihydroxymethamphetamine (THMA) is a neurotoxin and a metabolite of MDMA. It has structural similarity to the dopamine neurotoxin 6-hydroxydopamine, and produces lasting serotonin deficits when administered centrally.[1][2] See also
References1. ^{{cite journal | journal = European Journal of Pharmacology | volume = 221 | issue = 2–3 | date =1992 | pages = 281–288 | title = Long-term alteration in the central monoaminergic systems of the rat by 2,4,5-trihydroxyamphetamine but not by 2-hydroxy-4,5-methylenedioxymethamphetamine or2-hydroxy-4,5-methylenedioxyamphetamine |author1=Ikram Elayan |author2=James W. Gibb |author3=Glen R. Hanson |author4=Rodger L. Foltza |author5=Heng Keang Lima |author6=Michel Johnson | doi = 10.1016/0014-2999(92)90714-F}} {{Neurotoxins}}{{DEFAULTSORT:Trihydroxymethamphetamine, 2,4,5-}}{{amine-stub}}{{Neurotoxin-stub}}2. ^{{cite journal | journal = Chem Res Toxicol | date = 2011 | volume = 24 | issue = 6 | pages = 968–978 | doi = 10.1021/tx2001459 | pmc =3124246 | title = Synthesis and Neurotoxicity Profile of 2,4,5-Trihydroxymethamphetamine and its 6-(N-Acetylcystein-S-yl) Conjugate |author1=Anne Neudörffer |author2=Melanie Mueller |author3=Claire-Marie Martinez |author4=Annis Mechan |author5=Una McCann |author6=George A. Ricaurte |author7=Martine Largeron | pmid=21557581}} 3 : Methamphetamines|Recreational drug metabolites|Neurotoxins |
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