| 词条 | 2,5-Dimethoxy-4-isopropylamphetamine |
| 释义 |
| IUPAC_name = 1-[2,5-Dimethoxy-(propan-2-yl)phenyl]propan-2-amine | image = DOiPR_structure.png | width = 200px | legal_CA = Schedule I | legal_UK = Class A | CAS_number_Ref = | CAS_number = 42306-96-7 | CAS_supplemental = {{CAS|53581-56-9}} (hydrochloride salt) | PubChem = 44265275 | ChemSpiderID_Ref = | ChemSpiderID = 23108724 | C=14 | H=23 | N=1 | O=2 | molecular_weight = | smiles = COC1=C(C=C(C(=C1)C(C)C)OC)CC(C)N | StdInChI_Ref = | StdInChI = 1S/C14H23NO2/c1-9(2)12-8-13(16-4)11(6-10(3)15)7-14(12)17-5/h7-10H,6,15H2,1-5H3 | StdInChIKey_Ref = | StdInChIKey = UEEAUFJYLUJWQJ-UHFFFAOYAM }}2,5-Dimethoxy-4-isopropylamphetamine (also known as DOiP and DOiPr) is a psychedelic drug of the phenethylamine and amphetamine chemical classes.[1][2][3] It was first synthesized by Alexander Shulgin, and was described in his book PiHKAL (Phenethylamines i Have Known And Loved). Shulgin described DOiPR as being at least an order of magnitude weaker than DOPr, with doses of 20–30 mg required to produce valid changes in mental state.[4] Very little data exists about the pharmacological properties, metabolism, and toxicity of DOiPR. See also
References1. ^{{cite book | title=Interaction of phenylisopropylamines with central 5-HT2 receptors. Analysis by quantitative structure-activity relationships. |author1=Richard A. Glennon |author2=Mark R. Seggel | journal=ACS Symposium Series |date=November 1989 | volume=413 | pages=264–280 | doi=10.1021/bk-1989-0413.ch018|isbn = 978-0-8412-1702-7}} {{Hallucinogens}}{{Serotonergics}}{{Phenethylamines}}{{DEFAULTSORT:Dimethoxy-4-isopropylamphetamine, 2,5-}}{{hallucinogen-stub}}2. ^{{cite journal | title=A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors |author1=Mark R. Seggel |author2=M. Y. Yousif |author3=Robert A. Lyon |author4=Milt Titeler |author5=Bryan L. Roth |author6=Eva A. Suba |author7=Richard A. Glennon | journal=Journal of Medicinal Chemistry |date=March 1990 | volume=33 | issue=3 | pages=1032–1036 | doi=10.1021/jm00165a023 | pmid=2308135}} 3. ^{{cite journal | title=Structure-activity relations in psychotomimetic phenylalkylamines |author1=F. A. B. Aldous |author2=B. C. Barrass |author3=K. Brewster |author4=D. A. Buxton |author5=D. M. Green |author6=R. M. Pinder |author7=P. Rich |author8=M. Skeels |author9=K. J. Tutt | journal=Journal of Medicinal Chemistry |date=October 1974 | volume=17 | issue=10 | pages=1100–1111 | doi=10.1021/jm00256a016 | pmid=4418757}} 4. ^{{cite web | url=http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=71 | title=PiHKAL: A Chemical Love Story #71 DOPR | publisher=Transform Press | date=September 1991 | accessdate=27 June 2015 |author1=Shulgin, Alexander |author2=Shulgin, Ann | pages=978}} 5 : Substituted amphetamines|Designer drugs|Serotonin receptor agonists|Isopropyl compounds|Phenol ethers |
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