词条 | 2-deoxy-scyllo-inosose synthase |
释义 |
| Name = 2-deoxy-scyllo-inosose synthase | EC_number = 4.2.3.124 | CAS_number = | IUBMB_EC_number = 4/2/3/124 | GO_code = | image = | width = | caption = }}2-deoxy-scyllo-inosose synthase ({{EC number|4.2.3.124}}, btrC (gene), neoC (gene), kanC (gene)) is an enzyme with systematic name D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction D-glucose 6-phosphate 2-deoxy-L-scyllo-inosose + phosphate This enzyme requires Co2+. References1. ^{{cite journal | vauthors = Kudo F, Yamauchi N, Suzuki R, Kakinuma K | title = Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans | journal = The Journal of Antibiotics | volume = 50 | issue = 5 | pages = 424–8 | date = May 1997 | pmid = 9207913 | doi = 10.7164/antibiotics.50.424 }} 2. ^{{cite journal | vauthors = Kudo F, Hosomi Y, Tamegai H, Kakinuma K | title = Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocyclization enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics | journal = The Journal of Antibiotics | volume = 52 | issue = 2 | pages = 81–8 | date = February 1999 | pmid = 10344560 | doi = 10.7164/antibiotics.52.81 }} 3. ^{{cite journal | vauthors = Kudo F, Tamegai H, Fujiwara T, Tagami U, Hirayama K, Kakinuma K | title = Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase | journal = The Journal of Antibiotics | volume = 52 | issue = 6 | pages = 559–71 | date = June 1999 | pmid = 10470681 | doi = 10.7164/antibiotics.52.559 }} 4. ^{{cite journal | vauthors = Huang Z, Kakinuma K, Eguchi T | title = Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics | journal = Bioorganic Chemistry | volume = 33 | issue = 2 | pages = 82–9 | date = April 2005 | pmid = 15788164 | doi = 10.1016/j.bioorg.2004.09.002 }} 5. ^{{cite journal | vauthors = Thuy ML, Kharel MK, Lamichhane R, Lee HC, Suh JW, Liou K, Sohng JK | title = Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans | journal = Biotechnology Letters | volume = 27 | issue = 7 | pages = 465–70 | date = April 2005 | pmid = 15928851 | doi = 10.1007/s10529-005-2222-y }} 6. ^{{cite journal | vauthors = Tamegai H, Nango E, Koike-Takeshita A, Kudo F, Kakinuma K | title = Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans | journal = Bioscience, Biotechnology, and Biochemistry | volume = 66 | issue = 7 | pages = 1538–45 | date = July 2002 | pmid = 12224638 | doi = 10.1271/bbb.66.1538 }} 7. ^{{cite journal | vauthors = Tamegai H, Sawada H, Nango E, Aoki R, Hirakawa H, Iino T, Eguchi T | title = Roles of a 20 kDa protein associated with a carbocycle-forming enzyme involved in aminoglycoside biosynthesis in primary and secondary metabolism | journal = Bioscience, Biotechnology, and Biochemistry | volume = 74 | issue = 6 | pages = 1215–9 | year = 2010 | pmid = 20530911 | doi = 10.1271/bbb.90961 }} External links
1 : EC 4.2.3 |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。