“2-haloacid dehalogenase (configuration-retaining)”的意思、由来-开放百科全书

词条

2-haloacid dehalogenase (configuration-retaining)

释义

References
External links

{{Infobox enzyme
| Name = 2-haloacid dehalogenase (configuration-retaining)
| EC_number = 3.8.1.11
| CAS_number =
| IUBMB_EC_number = 3/8/1/11
| GO_code =
| image =
| width =
| caption =
}}2-haloacid dehalogenase (configuration-retaining) ({{EC number|3.8.1.11}}, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining).^[1]^[2] This enzyme catalyses the following chemical reaction

(1) (S)-2-haloacid + H₂O (S)-2-hydroxyacid + halide

(2) (R)-2-haloacid + H₂O (R)-2-hydroxyacid + halide

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.

References

1. ^{{cite journal | title = Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms |author1 = Weightman, A.J. |author2 =Weightman, A.L. |author3 =Slater, J.H. |journal = J. Gen. Microbiol. |year = 1982 |volume = 128 |pages = 1755–1762 |pmid = 7142958 |issue=8 |doi=10.1099/00221287-128-8-1755}}
2. ^{{cite journal | title = Bacterial 2-haloacid dehalogenases: Structures and catalytic properties |author1 = Soda, K. |author2 =Kurihara, T. |author3 =Liu, J.-Q. |author4 =Nardi-Dei, V. |author5 =Park, C. |author6 =Miyagi, M. |author7 =Tsunasawa, S. |author8 =Esaki, N. | journal = Pure Appl. Chem. |year = 1996 |volume = 68 |issue = 11 |pages = 2097–2103 |pmid = |doi=10.1351/pac199668112097}}

External links

{{MeshName|2-haloacid+dehalogenase+(configuration-retaining)}}

1 : EC 3.8.1

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