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词条 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
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  1. References

  2. External links

{{Infobox enzyme
| Name = 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
| EC_number = 3.7.1.14
| CAS_number =
| IUBMB_EC_number = 3/7/1/14
| GO_code =
| image =
| width =
| caption =
}}

2-hydroxy-6-oxonona-2,4-dienedioate hydrolase ({{EC number|3.7.1.14}}, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction:

  1. (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + succinate
  2. (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + fumarate

This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation.

References

1. ^{{cite journal | title = Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli |author1 = Burlingame, R. |author2 =Chapman, P.J. |journal = J. Bacteriol. |year = 1983 |volume = 155 |pages = 113–121 |pmid = 6345502 | issue = 1 | pmc = 217659}}
2. ^{{cite journal | title = Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation |author1 = Burlingame, R.P. |author2 =Wyman, L. |author3 =Chapman, P.J. |journal = J. Bacteriol. |year = 1986 |volume = 168 |pages = 55–64 |pmid = 3531186 | issue = 1 | pmc = 213419}}
3. ^{{cite journal | title = Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic clevage |author1 = Lam, W. W. Y |author2 =Bugg, T. D. H. |journal = J. Chem. Soc., Chem. Commun. |year = 1994 |volume = 10 |pages = 1163–1164 |pmid = | doi = 10.1039/c39940001163 | issue = 10 }}
4. ^{{cite journal | title = Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase |author1 = Lam, W.W. |author2 =Bugg, T.D. |journal = Biochemistry |year = 1997 |volume = 36 |pages = 12242–12251 |pmid = 9315862 | doi = 10.1021/bi971115r | issue = 40}}
5. ^{{cite journal | title = Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12 |author1 = Ferrández, A. |author2 =García, J.L. |author3 =Díaz, E. |journal = J. Bacteriol. |year = 1997 |volume = 179 |pages = 2573–2581 |pmid = 9098055 | issue = 8 | pmc = 179006}}
6. ^{{cite journal | title = Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12 |author1 = Díaz, E. |author2 =Ferrández, A. |author3 =García, J.L. |journal = J. Bacteriol. |year = 1998 |volume = 180 |pages = 2915–2923 |pmid = 9603882 | issue = 11 | pmc = 107259}}

External links

  • {{MeshName|2-hydroxy-6-oxonona-2,4-dienedioate+hydrolase}}
{{Carbon-carbon hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 3.7.1

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