| 词条 | 2-Nitropropane |
| 释义 |
| Name = | ImageFile = 2-Nitropropane.svg | ImageSize = 150px | ImageFile1 = 2-Nitropropane Ball and Stick.png | IUPACName = 2-Nitropropane | OtherNames = | SystematicName = | Section1 = {{Chembox Identifiers | Abbreviations = 2-NP | CASNo = 79-46-9 | PubChem = 398 | ChemSpiderID = 387 | EINECS = 201-209-1 | ChEBI = 16037 | SMILES = CC(C)[N+](=O)[O-] | InChI = 1/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3 | InChIKey = FGLBSLMDCBOPQK-UHFFFAOYAM | StdInChI = 1S/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3 | StdInChIKey = FGLBSLMDCBOPQK-UHFFFAOYSA-N | Section2 = {{Chembox Properties | C=3 | H=7 | N=1 | O=2 | Appearance = Colorless liquid[1] | Odor = Pleasant, fruity[2] | Density = 0.9821 g/cm3 | MeltingPtC = -91.3 | MeltingPt_notes = | BoilingPtC = 120.2 | BoilingPt_notes = | Solubility = 17 g/L[1] | SolubleOther = soluble in chloroform | pKa = 7.68 | LogP = 0.93 | RefractIndex = 1.3944 (20 °C) | Viscosity = 0.721 cP | VaporPressure = 13 mmHg (20°C)[2] | MagSus = -45.73·10−6 cm3/mol | Section3 = | Section4 = | Section5 = | Section6 = | Section7 = {{Chembox Hazards | MainHazards = Health hazard | GHSPictograms = {{GHS08}} | HPhrases = {{H-phrases|350}} | FlashPtC = 24 | FlashPt_notes = (open cup) 39 °C (closed cup) | AutoignitionPtC = 428 | ExploLimits = 2.6-11.0%[2] | NFPA-H = 3 | NFPA-R = 2 | NFPA-F = 3 | LD50 = 720 mg/kg | PEL = TWA 25 ppm (90 mg/m3)[2] | REL = Ca[2] | IDLH = Ca [100 ppm][2] | LC50 = 2703 ppm (mouse, 2 hr) 400 ppm (rat, 6 hr)[3] | LCLo = 714 ppm (cat, 5 hr) 2381 ppm (rabbit, 5 hr) 4622 ppm (guinea pig, 5 hr) 2353 ppm (cat, 1 hr)[3] }} 2-Nitropropane (2-NP) is a solvent. It is a colorless liquid and is classified as a nitro compound. Preparation2-Nitropropane is produced by the high-temperature vapor-phase nitration of propane, usually with impurities of 1-nitropropane. 2-Nitropropane is also produced as a volatile by-product that can be captured during Leonard's ring-closure hydantoin preparation [4] Uses2-Nitropropane is used primarily as a solvent and chemical intermediate. It is used in inks, paints, adhesives, varnishes, polymers, resins, fuel, and coatings.[5] 2-Nitropropane is also used as a feedstock for other industrial chemicals.[5] 2-Nitropropane has uses in the synthesis of phentermine, chlorphentermine, as well as in the synthesis of teclozan, etc. Safety2-Nitropropane is a constituent of tobacco smoke.[6] Based on studies in animals, it is reasonably anticipated to be a human carcinogen[5] and it is listed as an IARC Group 2B carcinogen.[7] References1. ^1 {{GESTIS|ZVG=22410}} {{DEFAULTSORT:Nitropropane, 2-}}2. ^1 2 3 4 5 {{PGCH|0460}} 3. ^1 {{IDLH|79469|2-Nitropropane}} 4. ^{{cite journal | title = Alternative synthesis of the anti-baldness compound RU58841 |author1=M. J. Leonard |author2=A. R. Lingham |author3=J. O. Niere |author4=N. R. C. Jackson |author5=P. G. McKay |author6=H. M. Hϋgel | journal = RSC Advances | date = 6 Mar 2014 | volume=4 | pages=14143–14148 | doi=10.1039/c4ra00332b}} 5. ^1 2 {{cite document | url = http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Nitropropane.pdf | title = Report on Carcinogens | edition = Twelfth | year = 2011 | publisher = National Toxicology Program, Department of Health and Human Services | journal = | access-date = 2012-06-13 | archive-url = https://web.archive.org/web/20120120103345/http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/Nitropropane.pdf | archive-date = 2012-01-20 | dead-url = yes | df = }} 6. ^{{cite journal|last1=Talhout|first1=Reinskje|last2=Schulz|first2=Thomas|last3=Florek|first3=Ewa|last4=Van Benthem|first4=Jan|last5=Wester|first5=Piet|last6=Opperhuizen|first6=Antoon|title=Hazardous Compounds in Tobacco Smoke|journal=International Journal of Environmental Research and Public Health|volume=8|issue=12|year=2011|pages=613–628|issn=1660-4601|doi=10.3390/ijerph8020613|pmid=21556207|pmc=3084482}} 7. ^Agents Classified by the IARC Monographs 3 : Nitroalkanes|Nitro solvents|Isopropyl compounds |
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