“2-Polyprenyl-6-hydroxyphenyl methylase”的意思、由来-开放百科全书

词条

2-Polyprenyl-6-hydroxyphenyl methylase

释义

References
External links

{{Infobox enzyme
| Name = 2-polyprenyl-6-hydroxyphenyl methylase
| EC_number = 2.1.1.222
| CAS_number =
| IUBMB_EC_number = 2/1/1/222
| GO_code =
| image =
| width =
| caption =
}}2-polyprenyl-6-hydroxyphenyl methylase ({{EC number|2.1.1.222}}, ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenyl methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol

UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.

References

1. ^{{cite journal | vauthors = Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF | title = Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 31 | pages = 21665–72 | date = July 1999 | pmid = 10419476 | doi = 10.1074/jbc.274.31.21665 }}
2. ^{{cite journal | vauthors = Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF | title = Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis | journal = Biochemistry | volume = 35 | issue = 30 | pages = 9797–806 | date = July 1996 | pmid = 8703953 | doi = 10.1021/bi9602932 }}

External links

{{MeshName|2-polyprenyl-6-hydroxyphenyl+methylase}}

1 : EC 2.1.1

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