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词条 3',5'-cyclic-AMP phosphodiesterase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = 3',5'-cyclic-AMP phosphodiesterase
| EC_number = 3.1.4.53
| CAS_number =
| IUBMB_EC_number = 3/1/4/53
| GO_code =
| image =
| width =
| caption =
}}3',5'-cyclic-AMP phosphodiesterase ({{EC number|3.1.4.53}}, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

adenosine 3',5'-cyclic phosphate + H2O AMP

This enzyme requires Mg2+ or Mn2+ for activity.

References

1. ^{{cite journal | vauthors = Alonso GD, Schoijet AC, Torres HN, Flawiá MM | title = TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi | journal = Molecular and Biochemical Parasitology | volume = 145 | issue = 1 | pages = 40–9 | date = January 2006 | pmid = 16225937 | doi = 10.1016/j.molbiopara.2005.09.005 }}
2. ^{{cite journal | vauthors = Bader S, Kortholt A, Snippe H, Van Haastert PJ | title = DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells | journal = The Journal of Biological Chemistry | volume = 281 | issue = 29 | pages = 20018–26 | date = July 2006 | pmid = 16644729 | doi = 10.1074/jbc.M600040200 }}
3. ^{{cite journal | vauthors = Rascón A, Soderling SH, Schaefer JB, Beavo JA | title = Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 7 | pages = 4714–9 | date = April 2002 | pmid = 11930017 | pmc = 123713 | doi = 10.1073/pnas.002031599 }}
4. ^{{cite journal | vauthors = Johner A, Kunz S, Linder M, Shakur Y, Seebeck T | title = Cyclic nucleotide specific phosphodiesterases of Leishmania major | journal = BMC Microbiology | volume = 6 | pages = 25 | date = March 2006 | pmid = 16522215 | pmc = 1431542 | doi = 10.1186/1471-2180-6-25 }}
5. ^{{cite journal | vauthors = Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E | title = Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei | journal = Biochimica et Biophysica Acta | volume = 1472 | issue = 3 | pages = 431–46 | date = November 1999 | pmid = 10564757 | doi = 10.1016/S0304-4165(99)00145-2 }}
6. ^{{cite journal | vauthors = Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H | title = Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25423–9 | date = October 1996 | pmid = 8810311 | doi = 10.1074/jbc.271.41.25423 }}

External links

  • {{MeshName|3',5'-cyclic-AMP+phosphodiesterase}}
{{Intracellular signaling peptides and proteins}}{{Esterases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 3.1.4

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