“3(or 17)a-hydroxysteroid dehydrogenase”的意思、由来-开放百科全书

词条

3(or 17)a-hydroxysteroid dehydrogenase

释义

References
External links

{{Infobox enzyme
| Name = 3(or 17)alpha-hydroxysteroid dehydrogenase
| EC_number = 1.1.1.209
| CAS_number = 83294-77-3
| IUBMB_EC_number = 1/1/1/209
| GO_code =
| image =
| width =
| caption =
}}3(or 17)alpha-hydroxysteroid dehydrogenase ({{EC number|1.1.1.209}}, 3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)⁺ oxidoreductase.^[1]^[2] This enzyme catalyses the chemical reaction

androsterone + NAD(P)+ 5alpha-androstane-3,17-dione + NAD(P)H + H⁺

This enzyme acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).

References

1. ^{{cite journal | title = A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme |author1 = Lau, P.C.K. |author2 =Layne, D.S. |author3 =Williamson, D.G. |journal = J. Biol. Chem. |year = 1982 |volume = 257 |pages = 9444–9449 |pmid = 6955302}}
2. ^{{cite journal | title = Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver |author1 = Lau, P.C.K. |author2 =Layne, D.S. |author3 =Williamson, D.G. |journal = J. Biol. Chem. |year = 1982 |volume = 257 |pages = 9450–9456 |pmid = 6955303}}

External links

{{MeshName|3(or+17)alpha-hydroxysteroid+dehydrogenase}}

4 : EC 1.1.1|NADH-dependent enzymes|NADPH-dependent enzymes|Enzymes of known structure

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