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| Name = 4,4'-diapophytoene synthase
| EC_number = 2.5.1.96
| CAS_number =
| IUBMB_EC_number = 2/5/1/96
| GO_code =
| image =
| width =
| caption =
}}4,4'-diapophytoene synthase ({{EC number|2.5.1.96}}, dehydrosqualene synthase, DAP synthase, C30 carotene synthase, CrtM) is an enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
2 (2E,6E)-farnesyl diphosphate4,4'-diapophytoene + 2 diphosphate (overall reaction)
(1a) 2 (2E,6E)-farnesyl diphosphate
(1b) presqualene diphosphate
This enzyme requires Mn2+. It is present in Staphylococcus aureus and some other bacteria such as Heliobacillus sp.
References
1. ^{{cite journal | vauthors = Umeno D, Tobias AV, Arnold FH | title = Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway | journal = Journal of Bacteriology | volume = 184 | issue = 23 | pages = 6690–9 | date = December 2002 | pmid = 12426357 | pmc = 135437 | doi = 10.1128/jb.184.23.6690-6699.2002 }}
2. ^{{cite journal | vauthors = Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Götz F | title = Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus | journal = The Journal of Biological Chemistry | volume = 280 | issue = 37 | pages = 32493–8 | date = September 2005 | pmid = 16020541 | doi = 10.1074/jbc.M505070200 }}
3. ^{{cite journal | vauthors = Ku B, Jeong JC, Mijts BN, Schmidt-Dannert C, Dordick JS | title = Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway | journal = Applied and Environmental Microbiology | volume = 71 | issue = 11 | pages = 6578–83 | date = November 2005 | pmid = 16269684 | pmc = 1287715 | doi = 10.1128/AEM.71.11.6578-6583.2005 }}
4. ^{{cite journal | vauthors = Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E | title = A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence | journal = Science | volume = 319 | issue = 5868 | pages = 1391–4 | date = March 2008 | pmid = 18276850 | pmc = 2747771 | doi = 10.1126/science.1153018 }}
2. ^{{cite journal | vauthors = Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Götz F | title = Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus | journal = The Journal of Biological Chemistry | volume = 280 | issue = 37 | pages = 32493–8 | date = September 2005 | pmid = 16020541 | doi = 10.1074/jbc.M505070200 }}
3. ^{{cite journal | vauthors = Ku B, Jeong JC, Mijts BN, Schmidt-Dannert C, Dordick JS | title = Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway | journal = Applied and Environmental Microbiology | volume = 71 | issue = 11 | pages = 6578–83 | date = November 2005 | pmid = 16269684 | pmc = 1287715 | doi = 10.1128/AEM.71.11.6578-6583.2005 }}
4. ^{{cite journal | vauthors = Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E | title = A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence | journal = Science | volume = 319 | issue = 5868 | pages = 1391–4 | date = March 2008 | pmid = 18276850 | pmc = 2747771 | doi = 10.1126/science.1153018 }}
External links
- {{MeshName|4,4'-diapophytoene+synthase}}
1 : EC 2.5.1
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