| 词条 | 4-Hydroxy-TEMPO |
| 释义 |
| Watchedfields = changed | verifiedrevid = 456502836 | ImageFile = 4-Hydroxy-TEMPO.svg | ImageSize = 175 | ImageAlt = Skeletal formula of 4-hydroxy-TEMPO | ImageFile1 = 4-Hydroxy-TEMPO radical ball.png | ImageSize1 = 175 | ImageAlt1 = Ball-and-stick model of the 4-hydroxy-TEMPO molecule | IUPACName = 1-λ1-oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol | OtherNames = tempol; tanol; TMPN; 4-Oxypiperidol; nitroxyl 2; HyTEMPO |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 2226-96-2 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 607023 | PubChem = 137994 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 121639 | SMILES = CC1(C)CC(O)CC(C)(C)N1[O] | InChI = 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3 | InChIKey = UZFMOKQJFYMBGY-UHFFFAOYSA-N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UZFMOKQJFYMBGY-UHFFFAOYSA-N |Section2={{Chembox Properties | C=9|H=18|N=1|O=2 | Appearance = Orange crystals | Density = | MeltingPtC = 71–73 | MeltingPt_ref = [1] | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | GHSPictograms = {{GHSp|GHS07}}[2] | GHSSignalWord = Warning[2] | HPhrases = {{H-phrases|302|315|319|335}}[2] | PPhrases = {{P-phrases|261|305+351+338}}[2] | FlashPt = | AutoignitionPt = }} }}4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable radical. Its major appeal over TEMPO is that is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.[3] In biochemical research, it has been investigated as an agent for limiting reactive oxygen species. It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.[4] It is often present as a structural element in hindered amine light stabilizers, which are commonly used stabilizers in plastics. References1. ^{{cite journal|last1=Zakrzewski|first1=Jerzy|last2=Krawczyk|first2=Maria|title=Reactions of Nitroxides. Part XII [1]. – 2,2,6,6-Tetramethyl-1-oxyl- 4-piperidyl Chloroformate – A New Reactive Nitroxyl Radical. A One-pot Synthesis of 2,2,6,6-Tetramethyl-1-oxyl-4-piperidyl N,N-Dialkyl-carbamates|journal=Zeitschrift für Naturforschung B|date=1 January 2011|volume=66|issue=5|doi=10.1515/znb-2011-0509}} {{DEFAULTSORT:Hydroxy-TEMPO, 4-}}2. ^1 2 3 {{Sigma-Aldrich|id=176141|name=4-Hydroxy-TEMPO|accessdate=2015-08-24}} 3. ^{{cite journal|last1=Ciriminna|first1=Rosaria|last2=Pagliaro|first2=Mario|title=Industrial Oxidations with Organocatalyst TEMPO and Its Derivatives|journal=Organic Process Research & Development|date=15 January 2010|volume=14|issue=1|pages=245–251|doi=10.1021/op900059x}} 4. ^{{cite journal | doi = 10.1124/pr.108.000240 | title = Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides | year = 2008 | last1 = Wilcox | first1 = C. S. | last2 = Pearlman | first2 = A. | journal = Pharmacological Reviews | volume = 60 | issue = 4 | pages = 418–69 | pmid = 19112152 | pmc = 2739999}} 3 : Free radicals|Amine oxides|Piperidines |
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