“5,6-dimethylbenzimidazole synthase”的意思、由来-开放百科全书

词条

5,6-dimethylbenzimidazole synthase

释义

References
External links

{{Infobox enzyme
| Name = 5,6-dimethylbenzimidazole synthase
| EC_number = 1.14.99.40
| CAS_number =
| IUBMB_EC_number = 1/14/99/40
| GO_code =
| image =
| width =
| caption =
}}5,6-dimethylbenzimidazole synthase ({{EC number|1.14.99.40}}, BluB) is an enzyme with systematic name FMNH₂ oxidoreductase (5,6-dimethylbenzimidazole forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

FMNH₂ + NADH + H⁺ + O₂ 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD⁺ + other product

The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH₂ and 2-H from the ribityl 1'-pro-S hydrogen.

References

1. ^{{cite journal | vauthors = Gray MJ, Escalante-Semerena JC | title = Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 8 | pages = 2921–6 | date = February 2007 | pmid = 17301238 | pmc = 1815282 | doi = 10.1073/pnas.0609270104 }}
2. ^{{cite journal | vauthors = Ealick SE, Begley TP | title = Biochemistry: molecular cannibalism | journal = Nature | volume = 446 | issue = 7134 | pages = 387–8 | date = March 2007 | pmid = 17377573 | doi = 10.1038/446387a }}
3. ^{{cite journal | vauthors = Taga ME, Larsen NA, Howard-Jones AR, Walsh CT, Walker GC | title = BluB cannibalizes flavin to form the lower ligand of vitamin B12 | journal = Nature | volume = 446 | issue = 7134 | pages = 449–53 | date = March 2007 | pmid = 17377583 | pmc = 2770582 | doi = 10.1038/nature05611 }}

External links

{{MeshName|5,6-dimethylbenzimidazole+synthase}}

1 : EC 1.14.99

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。