| 词条 | 5-Fluoro-5-deoxy-D-ribose 1-phosphate |
| 释义 |
| Name=5-Fluoro-5-deoxy-D-ribose 1-phosphate | ImageFile = 5-Fluoro-5-deoxy-D-ribose-1-phosphate.svg | ImageSize = 200px | IUPACName = 5-Deoxy-5-fluoro-1-O-phosphonato-D-ribofuranose | OtherNames = |Section1={{Chembox Identifiers | CASNo = | PubChem = 49859615 | PubChem_Comment = (dianion) | ChemSpiderID = 21169315 | ChemSpiderID_Comment = (dianion) | SMILES = O[C@@H]1[C@H](O)[C@@H](CF)OC1OP(=O)(O)O |Section2={{Chembox Properties | C=5 | H=10 | F=1 | O=7 | P=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}5-Fluoro-5-deoxy-D-ribose 1-phosphate is metabolite formed during the biosynthesis of organofluorides. It is formed by the purine nucleoside phosphorylase mediated phosphorolytic cleavage of 5'-deoxy-5'-fluoroadenosine.[1] It is isomerized to 5-fluoro-5-deoxy-ribulose-1-phosphate which is then cleaved by an aldolase to release fluoroacetaldehyde.[2] References1. ^{{cite journal | author = O'Hagan D | author2 = Schaffrath C | author3 = Cobb SL | author4 = Hamilton JT | author5 = Murphy CD | date = 2002 | title = Biochemistry: biosynthesis of an organofluorine molecule | journal = Nature | volume = 416 | pages = 279 | pmid = 11907567 | doi = 10.1038/416279a | issue = 6878}} {{DEFAULTSORT:Fluoro-5-deoxy-D-ribose 1-phosphate, 5-}}2. ^{{cite journal | author = Hai Deng | author2 = Stuart M. Cross | author3 = Ryan P. McGlinchey| author4 = John T.G. Hamilton | author5 = David O'Hagan | date = 2008 | title = In Vitro Reconstituted Biotransformation of 4-Fluorothreonine from Fluoride Ion: Application of the Fluorinase | journal = Chemistry and Biology | volume = 15 | pages = 1268–1276 | doi = 10.1016/j.chembiol.2008.10.012| pmid = 19101471 | issue = 12}} 4 : Organofluorides|Organophosphates|Halogen-containing natural products|Fluorine-containing natural products |
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