| 词条 | 5-MAPDB |
| 释义 |
| IUPAC_name = 1-(2,3-dihydrobenzofuran-5-yl)-N-methylpropan-2-amine | image = 5-MAPDB_structure.png | width = 240 | legal_AU = Analogue of MDMA | legal_CA = Analogue of amphetamine | legal_UK = Temporary class | legal_US = analogue | legal_US_comment = (MDMA) | legal_status = | dependency_liability = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 1354631-78-9 | CAS_supplemental = | ATCvet = | PubChem = 112500533 | PubChemSubstance = | IUPHAR_ligand = | DrugBank = | UNII = FS5Z21939Z | KEGG = | ChEBI = | ChEMBL = | synonyms = | ChemSpiderID = 52085108 | chemical_formula = | C=12 | H=17 | N=1 | O=1 | molecular_weight = 191.27 | smiles = CC(NC)CC1=CC(CCO2)=C2C=C1 | StdInChI = 1S/C12H17NO/c1-9(13-2)7-10-3-4-12-11(8-10)5-6-14-12/h3-4,8-9,13H,5-7H2,1-2H3 | StdInChIKey = PLQTZOCLUHHCOI-UHFFFAOYSA-N | density = | melting_point = | melting_high = | melting_notes = | boiling_point = | boiling_notes = | solubility = | specific_rotation = | sec_combustion = }}5-MAPDB (1-(2,3-dihydrobenzofuran-5-yl)-N-methylpropan-2-amine) is a chemical compound which might be an entactogenic drug. It is structurally related to drugs like 5-APDB and 5-MAPB, which have similar effects to MDMA and have been used as recreational drugs. 5-MAPDB has been studied to determine its pharmacological activity, and was found to be a relatively selective serotonin releaser, though with weaker actions as a releaser of other monoamines and 5-HT2 receptor family agonist,[1] similar to older compounds such as 5-APDB.[2] Legality5-MAPDB was banned in the UK in June 2013 as a temporary class drug along with 9 other related compounds, despite having never been sold as a street drug itself. This was due to concerns that it would have similar effects to drugs such as 5-APB that had been widely sold already, and 5-MAPDB might therefore be likely to become used recreationally also, if it were not banned preemptively.[3] References1. ^{{cite journal | last1 = Rickli | first1 = A | last2 = Kopf | first2 = S | last3 = Hoener | first3 = MC | last4 = Liechti | first4 = ME | date = Jul 2015 | title = Pharmacological profile of novel psychoactive benzofurans | journal = British Journal of Pharmacology | volume = 172 | issue = 13| pages = 3412–25 | doi = 10.1111/bph.13128 | pmid = 25765500 | pmc=4500375}} {{Entactogens|state=expanded}}{{Serotonergics}}{{Phenethylamines}}2. ^{{cite journal | author = Monte AP | author2 = Marona-Lewicka D | author3 = Cozzi NV | author4 = Nichols DE | title = Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine | journal = Journal of Medicinal Chemistry | volume = 36 | issue = 23 | pages = 3700–6 |date=November 1993 | pmid = 8246240 | doi = 10.1021/jm00075a027| url = }} 3. ^{{cite web | url = https://www.gov.uk/government/publications/temporary-class-drug-order-report-on-benzofury-and-nbome-compounds | title = Temporary class drug order report on 5-6APB and NBOMe compounds | accessdate = 2013-07-11 | date = 4 Jun 2013 | publisher = UK Home Office}} 4 : Methamphetamines|Benzofurans|Designer drugs|Entactogens and empathogens |
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