| 词条 | 5α-Dihydrocorticosterone |
| 释义 |
| ImageFile = 5α-Dihydrocorticosterone.svg | ImageSize = 200px | ImageAlt = | IUPACName = (5S,8S,9S,10S,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 298-25-9 | ChemSpiderID = 2338305 | InChI = InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12,14-17,19,22,24H,3-11H2,1-2H3/t12-,14-,15-,16+,17-,19+,20-,21-/m0/s1 | PubChem = 3080546 | SMILES = CC12CCC(=O)CC1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O | Section2 = {{Chembox Properties | Formula = C21H32O4 | MolarMass = 348.47638 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}5α-Dihydrocorticosterone (5α-DHC, 5α-DHB), also known as 11β,21-dihydroxy-5α-pregnane-3,20-dione, is a naturally occurring, endogenous glucocorticoid steroid hormone and neurosteroid.[1][2][3] It is biosynthesized from corticosterone by the enzyme 5α-reductase.[4][5][6] DHC has central depressant effects and impairs long-term potentiation in animals.[7][8] See also
References1. ^{{cite book|author1=R.A. Hill|author2=H.L.J. Makin|author3=D.N. Kirk|author4=G.M. Murphy|title=Dictionary of Steroids|url=https://books.google.com/books?id=AI7EnUyeEtUC&pg=PA218|date=23 May 1991|publisher=CRC Press|isbn=978-0-412-27060-4|pages=218–}} {{Endogenous steroids}}{{Glucocorticoid receptor modulators}}{{DEFAULTSORT:Dihydrocorticosterone, 5α-}}{{Steroid-stub}}2. ^{{cite journal|last1=McInnes|first1=K. J.|last2=Kenyon|first2=C. J.|last3=Chapman|first3=K. E.|last4=Livingstone|first4=D. E. W.|last5=Macdonald|first5=L. J.|last6=Walker|first6=B. R.|last7=Andrew|first7=R.|title=5 -Reduced Glucocorticoids, Novel Endogenous Activators of the Glucocorticoid Receptor|journal=Journal of Biological Chemistry|volume=279|issue=22|year=2004|pages=22908–22912|issn=0021-9258|doi=10.1074/jbc.M402822200|pmid=15044432}} 3. ^{{cite journal | vauthors = Magnaghi V | title = GABA and neuroactive steroid interactions in glia: new roles for old players? | journal = Curr Neuropharmacol | volume = 5 | issue = 1 | pages = 47–64 | year = 2007 | pmid = 18615153 | pmc = 2435342 | doi = 10.2174/157015907780077132| url = }} 4. ^{{cite book|author=Abraham Weizman|title=Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment|url=https://books.google.com/books?id=uABKkFdPjhkC&pg=PA48|date=1 February 2008|publisher=Springer Science & Business Media|isbn=978-1-4020-6854-6|pages=48–}} 5. ^{{cite book|title=Neurosteroids and Brain Function|url=https://books.google.com/books?id=BJumUEbiaPYC&pg=PA147|date=12 December 2001|publisher=Academic Press|isbn=978-0-08-054423-6|pages=147–}} 6. ^{{cite book|author1=N. Kato|author2=M. Kawata|author3=R.K. Pitman|title=PTSD: Brain Mechanisms and Clinical Implications|url=https://books.google.com/books?id=d_A4K1aC8bUC&pg=PA125|date=3 July 2007|publisher=Springer Science & Business Media|isbn=978-4-431-29567-9|pages=125–}} 7. ^{{cite journal|last1=Dubrovsky|first1=B.|last2=Williams|first2=D.|last3=Kraulis|first3=I.|title=Effects of corticosterone and 5?-dihydrocorticosterone on brain excitability in the rat|journal=Journal of Neuroscience Research|volume=14|issue=1|year=1985|pages=117–128|issn=0360-4012|doi=10.1002/jnr.490140111}} 8. ^{{cite journal|last1=Dubrovsky|first1=B.O.|last2=Liquornik|first2=M.S.|last3=Noble|first3=P.|last4=Gijsbers|first4=K.|title=Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation|journal=Brain Research Bulletin|volume=19|issue=6|year=1987|pages=635–638|issn=0361-9230|doi=10.1016/0361-9230(87)90049-9}} 4 : Diketones|Glucocorticoids|Neurosteroids|Pregnanes |
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