- See also
- References
- External links
| Name = Δ4-3-Oxosteroid 5β-reductase
| EC_number = 1.3.1.3
| CAS_number = 2604034
| IUBMB_EC_number = 1/3/1/3
| GO_code =
| image =
| width =
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}}5β-Reductase, or Δ4-3-oxosteroid 5β-reductase ({{EC number|1.3.1.3}}, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
(1) 5β-cholestan-3-one + NADP+cholest-4-en-3-one + NADPH + H+
(2) 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+
The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. It can also act on aldosterone, corticosterone and cortisol, to some extent.
See also
- Steroidogenic enzyme
- 5α-Reductase
References
1. ^{{cite journal | vauthors = Dorfman RI, Forchielli E | title = Separation of delta 4-5 alpha-hydrogenases from rat liver homogenates | journal = The Journal of Biological Chemistry | volume = 223 | issue = 1 | pages = 443–8 | date = November 1956 | pmid = 13376613 | last-author-amp = yes }}
2. ^{{cite journal | vauthors = Brown-Grant K, Forchielli E, Dorfman RI | title = The delta4-hydrogenases of guinea pig adrenal gland | journal = The Journal of Biological Chemistry | volume = 235 | pages = 1317–20 | date = May 1960 | pmid = 13805063 | last-author-amp = yes }}
3. ^{{cite journal | title = Enzymatic introduction of double bonds into steroid ring A |author = Levy, H.R. |author2 = Talalay, P. |last-author-amp = yes |journal = J. Am. Chem. Soc. |year = 1957 |volume = 79 |pages = 2658–2659 |pmid = |doi=10.1021/ja01567a089}}
4. ^{{cite journal | vauthors = Tomkins GM | title = The enzymatic reduction of delta 4-3-ketosteroids | journal = The Journal of Biological Chemistry | volume = 225 | issue = 1 | pages = 13–24 | date = March 1957 | pmid = 13416214 }}
5. ^{{cite journal | vauthors = Sugimoto Y, Yoshida M, Tamaoki B | title = Purification of 5 beta-reductase from hepatic cytosol fraction of chicken | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 37 | issue = 5 | pages = 717–24 | date = December 1990 | pmid = 2278855 | doi = 10.1016/0960-0760(90)90356-p | last-author-amp = yes }}
6. ^{{cite journal | vauthors = Furuebisu M, Deguchi S, Okuda K | title = Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase | journal = Biochimica et Biophysica Acta | volume = 912 | issue = 1 | pages = 110–4 | date = March 1987 | pmid = 3828348 | doi = 10.1016/0167-4838(87)90253-6 | last-author-amp = yes }}
7. ^{{cite journal | vauthors = Okuda A, Okuda K | title = Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase | journal = The Journal of Biological Chemistry | volume = 259 | issue = 12 | pages = 7519–24 | date = June 1984 | pmid = 6736016 | last-author-amp = yes }}
8. ^{{cite journal | vauthors = Charbonneau A, The VL | title = Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme | journal = Biochimica et Biophysica Acta | volume = 1517 | issue = 2 | pages = 228–35 | date = January 2001 | pmid = 11342103 | doi = 10.1016/s0167-4781(00)00278-5 | last-author-amp = yes }}
9. ^{{cite journal | vauthors = Kondo KH, Kai MH, Setoguchi Y, Eggertsen G, Sjöblom P, Setoguchi T, Okuda KI, Björkhem I | title = Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme | journal = European Journal of Biochemistry | volume = 219 | issue = 1-2 | pages = 357–63 | date = January 1994 | pmid = 7508385 | doi = 10.1111/j.1432-1033.1994.tb19947.x | last-author-amp = yes }}
2. ^{{cite journal | vauthors = Brown-Grant K, Forchielli E, Dorfman RI | title = The delta4-hydrogenases of guinea pig adrenal gland | journal = The Journal of Biological Chemistry | volume = 235 | pages = 1317–20 | date = May 1960 | pmid = 13805063 | last-author-amp = yes }}
3. ^{{cite journal | title = Enzymatic introduction of double bonds into steroid ring A |author = Levy, H.R. |author2 = Talalay, P. |last-author-amp = yes |journal = J. Am. Chem. Soc. |year = 1957 |volume = 79 |pages = 2658–2659 |pmid = |doi=10.1021/ja01567a089}}
4. ^{{cite journal | vauthors = Tomkins GM | title = The enzymatic reduction of delta 4-3-ketosteroids | journal = The Journal of Biological Chemistry | volume = 225 | issue = 1 | pages = 13–24 | date = March 1957 | pmid = 13416214 }}
5. ^{{cite journal | vauthors = Sugimoto Y, Yoshida M, Tamaoki B | title = Purification of 5 beta-reductase from hepatic cytosol fraction of chicken | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 37 | issue = 5 | pages = 717–24 | date = December 1990 | pmid = 2278855 | doi = 10.1016/0960-0760(90)90356-p | last-author-amp = yes }}
6. ^{{cite journal | vauthors = Furuebisu M, Deguchi S, Okuda K | title = Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase | journal = Biochimica et Biophysica Acta | volume = 912 | issue = 1 | pages = 110–4 | date = March 1987 | pmid = 3828348 | doi = 10.1016/0167-4838(87)90253-6 | last-author-amp = yes }}
7. ^{{cite journal | vauthors = Okuda A, Okuda K | title = Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase | journal = The Journal of Biological Chemistry | volume = 259 | issue = 12 | pages = 7519–24 | date = June 1984 | pmid = 6736016 | last-author-amp = yes }}
8. ^{{cite journal | vauthors = Charbonneau A, The VL | title = Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme | journal = Biochimica et Biophysica Acta | volume = 1517 | issue = 2 | pages = 228–35 | date = January 2001 | pmid = 11342103 | doi = 10.1016/s0167-4781(00)00278-5 | last-author-amp = yes }}
9. ^{{cite journal | vauthors = Kondo KH, Kai MH, Setoguchi Y, Eggertsen G, Sjöblom P, Setoguchi T, Okuda KI, Björkhem I | title = Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme | journal = European Journal of Biochemistry | volume = 219 | issue = 1-2 | pages = 357–63 | date = January 1994 | pmid = 7508385 | doi = 10.1111/j.1432-1033.1994.tb19947.x | last-author-amp = yes }}
External links
- {{MeshName|Delta4-3-oxosteroid+5beta-reductase}}
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