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词条 6-(2-Aminopropyl)indole
释义

  1. Legality

  2. References

{{Drugbox
| IUPAC_name = 1-(1H-Indol-6-yl)propan-2-amine
| image = 6-API_structure.tif
| tradename =
| pregnancy_category =
| legal_status = Uncontrolled (but covered under the Federal Analogue Act in the United States and Australia and likely under similar bills in other countries)
| routes_of_administration = Oral
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number = 22196-72-1
| ATC_prefix =
| ATC_suffix =
| PubChem = 30999
| ChemSpiderID = 28759
| C=11 | H=14 | N=2
| molecular_weight = 174.24 g/mol
| smiles = C1=C2C(=CC=C1CC(C)N([H])[H])C=C[N]2[H]
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C11H14N2/c1-8(12)6-9-2-3-10-4-5-13-11(10)7-9/h2-5,7-8,13H,6,12H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QCFIFKAOUKPFPU-UHFFFAOYSA-N
}}6-(2-Aminopropyl)indole (6-API, 6-IT) is an indole derivative which was first identified being sold on the designer drug market by a laboratory in the Czech Republic in July 2016.[1]

Alexander Shulgin says in his book TiHKAL "From the normal 3-position to the 2, the 4, the 5, the 6 or the 7-positions. All five alpha-methyltryptamine isomers are known, but only one is known to be active in man as a CNS active material. This is the 5-isomer, 5-(2-aminopropyl)indole or 5-IT" .

Studies in dogs have also shown the drug to increase hemoglobin levels in the bloodstream.[2]

Legality

  • 6-API is a positional isomer of αMT, and as such may be covered by the analogue act in the USA (depending on the nature of its psychoactive effect).
  • 6-API / 6-IT is illegal in the UK, as it was banned as a temporary class drug in June 2013, along with 9 other related compounds.[3] On March 5, 2014 the UK Home Office announced that 6-API would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs.[4]
  • 6-API is covered by the Australian analogue act as an analogue of MDA "by the replacement of up to 2 carbocyclic or heterocyclic ring structures with different carbocyclic or heterocyclic ring structures"[5]

References

1. ^Europol 2016 Annual Report on the implementation of Council Decision 2005/387/JHA
2. ^{{cite journal|last=Maxwell|first=G. M.|title=The effects of an indole derivative 6-(2′-Aminopropyl indole) on the general and coronary haemodynamics of the intact dog|journal=Cellular and Molecular Life Sciences|year=1964|volume=20|issue=9|pages=526–527|doi=10.1007/BF02154095}}
3. ^{{cite web | url = https://www.gov.uk/government/publications/temporary-class-drug-order-report-on-benzofury-and-nbome-compounds | title = Temporary class drug order report on 5-6APB and NBOMe compounds | accessdate = 2013-07-11 | date = 4 Jun 2013 | publisher = UK Home Office}}
4. ^{{cite web | url = http://www.legislation.gov.uk/ukdsi/2014/9780111110904 | title = The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014 | accessdate = 2014-03-11 | author = UK Home Office | date = 2014-03-05 | publisher = UK Government}}
5. ^{{cite web | url = http://www.comlaw.gov.au/ComLaw/Legislation/ActCompilation1.nsf/0/1B4A2DD73EF9A4BBCA2576040024B600/$file/CriminalCode1995_WD02.pdf | title = Criminal Code Act 1995 | accessdate = 2012-02-08 | date = 2009-08-05 | format = PDF | publisher = Australian Government | quote = PAGE 503}}
{{Entactogens|state=expanded}}{{Stimulants}}{{Adrenergics}}{{Dopaminergics}}{{Serotonergics}}{{Phenethylamines}}{{DEFAULTSORT:Aminopropyl)indole, 6-(2-}}

3 : Indoles|Stimulants|Entactogens and empathogens

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