| 词条 | 6-carboxytetrahydropterin synthase |
| 释义 |
| Name = 6-carboxytetrahydropterin synthase | EC_number = 4.1.2.50 | CAS_number = | IUBMB_EC_number = 4/1/2/50 | GO_code = | image = 4ntn.jpg | width = 270 | caption = 6-Carboxy-5,6,7,8-tetrahydropterin synthase hexamer, E.Coli }} 6-carboxytetrahydropterin synthase ({{EC number|4.1.2.50}}, CPH4 synthase, queD (gene), ToyB , ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming).[1][2] This enzyme catalyses the following reversible chemical reaction. 7,8-dihydroneopterin 3'-triphosphate + H2O {{eqm}} 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate This enzyme binds Zn2+. It is isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin.[2] References1. ^{{cite journal | vauthors = Cicmil N, Shi L | title = Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis | journal = Acta Crystallographica Section F | volume = 64 | issue = Pt 2 | pages = 119–22 | date = February 2008 | pmid = 18259064 | pmc = 2374184 | doi = 10.1107/s1744309108000924 }} 2. ^1 {{cite journal | vauthors = McCarty RM, Somogyi A, Bandarian V | title = Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase | journal = Biochemistry | volume = 48 | issue = 11 | pages = 2301–3 | date = March 2009 | pmid = 19231875 | pmc = 3227869 | doi = 10.1021/bi9001437 }} External links
1 : EC 4.1.2 |
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