| 词条 | 6β-Naltrexol-d4 |
| 释义 |
| IUPAC_name = (1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)(13,14,15,15-²H₄)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-triene-10,14,17-triol | image = 6β-Naltrexol-d4.png | CAS_number = 1279034-32-0 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = | ATC_prefix = None | ATC_suffix = | PubChem = 46782432 | DrugBank = | C=20 | H=21 | D=4 | N=1 | O=4 | molecular_weight = | smiles = O[C@@]1(C(C[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@]1([C@]2(CCN3CC6CC6)c45)[2H])([2H])[2H])[2H] | synonyms = | StdInChI = 1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1/i5D2,14D,18D | StdInChIKey = JLVNEHKORQFVQJ-NCRVCFHNSA-N | ChemSpiderID = 58783513 | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}6β-Naltrexol-d4, also known as 6β-hydroxynaltrexone-d4, is a deuterium-labeled form of 6β-Naltrexol used for NMR imaging. Unlike opioid inverse agonists such as naloxone and naltrexone (which are often dubbed "antagonists" for simplicity's sake), 6β-naltrexol and 6β-naltrexol-d4 are opioid neutral antagonists.[1] References1. ^The Relative Potency of Inverse Opioid Agonists and a Neutral Opioid Antagonist in Precipitated Withdrawal and Antagonism of Analgesia and Toxicity. Sunil Sirohi, Shveta V. Dighe, Priyanka A. Madia and Byron C. Yoburn {{Opioidergics}}{{DEFAULTSORT:Naltrexol-d4, 6beta-}}{{nervous-system-drug-stub}} 4 : Opioid antagonists|Morphinans|Semisynthetic opioids|Kappa antagonists |
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