请输入您要查询的百科知识：

　

词条 7,8-Dihydroxyflavone
释义

  1. See also

  2. References

{{medref|date=August 2018}}{{Drugbox
| Verifiedfields =
| Watchedfields =
| verifiedrevid =
| IUPAC_name = 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
| image = 7,8-dihydroxyflavone.svg
| width = 225px
| tradename =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| bioavailability = ~5% (in mice)[1]
| protein_bound =
| metabolism =
| elimination_half-life = < 30 minutes (in mice)[1]
| excretion =
| CAS_number_Ref =
| CAS_number = 38183-03-8
| CAS_supplemental =
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =
| PubChem = 1880
| IUPHAR_ligand =
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID = 1809
| UNII =
| KEGG =
| ChEBI = 140464
| ChEMBL =
| C=15 | H=10 | O=4
| molecular_weight = 254.238 g/mol
| SMILES = c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O
| StdInChI_Ref =
| StdInChI = 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
| StdInChIKey_Ref =
| StdInChIKey = COCYGNDCWFKTMF-UHFFFAOYSA-N
| synonyms = 7,8-DHF
}}7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves.[2][3][4] It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).[5][6][7] 7,8-DHF is both orally bioavailable and able to penetrate the blood–brain barrier.[8][9] A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R13 (and, formerly, R7), is under development for the treatment of Alzheimer's disease.[10][11]

7,8-DHF has demonstrated therapeutic efficacy in animal models of a variety of central nervous system disorders,[7] including depression,[8] Alzheimer's disease,[12][13][14] cognitive deficits in schizophrenia,[15] Parkinson's disease,[5] Huntington's disease,[16] amyotrophic lateral sclerosis,[17] traumatic brain injury,[18] cerebral ischemia,[19][20] fragile X syndrome,[21] and Rett syndrome.[22] 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment[23] and enhances memory consolidation and emotional learning in healthy rodents.[24][25] In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor,[26] and protects against glutamate-induced excitotoxicity,[27] 6-hydroxydopamine-induced dopaminergic neurotoxicity,[28] and oxidative stress-induced genotoxicity.[29] It was also found to block methamphetamine-induced dopaminergic neurotoxicity, an effect which, in contrast to the preceding, was found to be TrkB-dependent.[30]

In 2017, evidence was published suggesting that 7,8-DHF and various other reported small-molecule TrkB agonists might not actually be direct agonists of the TrkB and might be mediating their observed effects by other means.[31][32]

7,8-DHF has been found to act as a weak aromatase inhibitor in vitro (Ki = 10 μM),[33] though there is evidence to suggest that this might not be the case in vivo.[5] In addition, it has been found to inhibit aldehyde dehydrogenase and estrogen sulfotransferase in vitro (Ki = 35 μM and 1–3 μM, respectively), though similarly to the case of aromatase, these activities have not yet been confirmed in vivo.[5] Unlike many other flavonoids, 7,8-DHF does not show any inhibitory activity on 17β-hydroxysteroid dehydrogenase.[34] 7,8-DHF has also been observed to possess in vitro antiestrogenic effects at very high concentrations (Ki = 50 μM).[35][36]

A variety of close structural analogues of 7,8-DHF have also been found to act as TrkB agonists in vitro, including diosmetin (5,7,3'-trihydroxy-4'-methoxyflavone), norwogonin (5,7,8-trihydroxyflavone), 4'-dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), 7,8,3'-trihydroxyflavone, 7,3'-dihydroxyflavone, 7,8,2'-trihydroxyflavone, 3,7,8,2'-tetrahydroxyflavone, and 3,7-dihydroxyflavone.[37] The highly hydroxylated analogue gossypetin (3,5,7,8,3',4'-hexahydroxyflavone), conversely, appears to be an antagonist of TrkB in vitro.[37]

See also

  • List of investigational antidepressants
  • Tropomyosin receptor kinase B § Agonists

References

1. ^1 {{cite patent | country = US | number = 20150274692 | status = application | title = 7,8-Dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto | pubdate = 2015-10-01 | fdate = 2013-11-01 | pridate = 2012-11-05 | invent1 = Keqiang Ye | assign1 = Emory University | url = https://www.google.com/patents/US20150274692}}
2. ^{{cite journal|last1=Andero|first1=R.|last2=Ressler|first2=K.J.|title=Fear extinction and BDNF: translating animal models of PTSD to the clinic|journal=Genes, Brain and Behavior|volume=11|issue=5|year=2012|pages=503–512|issn=1601-1848|doi=10.1111/j.1601-183X.2012.00801.x|pmc=3389160}}
3. ^{{cite journal|last1=Colombo|first1=Paola S.|last2=Flamini|first2=Guido|last3=Christodoulou|first3=Michael S.|last4=Rodondi|first4=Graziella|last5=Vitalini|first5=Sara|last6=Passarella|first6=Daniele|last7=Fico|first7=Gelsomina|title=Farinose alpine Primula species: Phytochemical and morphological investigations|journal=Phytochemistry|volume=98|year=2014|pages=151–159|issn=0031-9422|doi=10.1016/j.phytochem.2013.11.018|pmid=24345641|url=https://air.unimi.it/bitstream/2434/233766/2/Farinose%20alpine%20Primula-Phyto%202014.pdf}}
4. ^{{cite web | url = https://www.sciencedaily.com/releases/2015/03/150305125355.htm | title = Molecule found in tree leaves helps female mice combat weight gain; males unaffected | accessdate = 2015-03-19 | author = Cell Press | publisher = ScienceDaily | year = 2015}}
5. ^1 2 3 {{cite journal | vauthors = Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K | title = A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 107 | issue = 6 | pages = 2687–92 | year = 2010 | pmid = 20133810 | pmc = 2823863 | doi = 10.1073/pnas.0913572107 | url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=20133810}}
6. ^{{cite journal | vauthors = Liu X, Obianyo O, Chan CB, Huang J, Xue S, Yang JJ, Zeng F, Goodman M, Ye K | title = Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor | journal = J. Biol. Chem. | volume = 289 | issue = 40 | pages = 27571–84 | year = 2014 | pmid = 25143381 | doi = 10.1074/jbc.M114.562561 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=25143381 | pmc=4183797}}
7. ^1 {{cite journal | vauthors = Zeng Y, Wang X, Wang Q, Liu S, Hu X, McClintock SM | title = Small molecules activating TrkB receptor for treating a variety of CNS disorders | journal = CNS Neurol Disord Drug Targets | volume = 12 | issue = 7 | pages = 1066–77 | year = 2013 | pmid = 23844685 | doi = 10.2174/18715273113129990089| url = http://www.eurekaselect.com/112836/article}}
8. ^1 {{cite journal | vauthors = Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K | title = A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect | journal = J. Med. Chem. | volume = 53 | issue = 23 | pages = 8274–86 | year = 2010 | pmid = 21073191 | pmc = 3150605 | doi = 10.1021/jm101206p }}
9. ^{{cite journal | vauthors = Liu X, Chan CB, Qi Q, Xiao G, Luo HR, He X, Ye K | title = Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression | journal = J. Med. Chem. | volume = 55 | issue = 19 | pages = 8524–37 | year = 2012 | pmid = 22984948 | pmc = 3491656 | doi = 10.1021/jm301099x }}
10. ^{{cite journal | vauthors = Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K | title = The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 115 | issue = 3 | pages = 578–583 | date = January 2018 | pmid = 29295929 | pmc = 5777001 | doi = 10.1073/pnas.1718683115 | url = }}
11. ^{{cite journal|last1=Liu|first1=Chaoyang|last2=Chan|first2=Chi Bun|last3=Ye|first3=Keqiang|title=7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders|journal=Translational Neurodegeneration|volume=5|issue=1|pages=2|year=2016|issn=2047-9158|doi=10.1186/s40035-015-0048-7|pmc=4702337|pmid=26740873}}
12. ^{{cite journal | vauthors = Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM | title = 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss | journal = PLoS ONE | volume = 9 | issue = 3 | pages = e91453 | year = 2014 | pmid = 24614170 | pmc = 3948846 | doi = 10.1371/journal.pone.0091453 | url = http://dx.plos.org/10.1371/journal.pone.0091453}}
13. ^{{cite journal | vauthors = Chen C, Li XH, Zhang S, Tu Y, Wang YM, Sun HT | title = 7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction | journal = Rejuvenation Res | volume = 17 | issue = 3 | pages = 249–54 | year = 2014 | pmid = 24325271 | doi = 10.1089/rej.2013.1519 }}
14. ^{{cite journal | vauthors = Zhang Z, Liu X, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K | title = 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease | journal = Neuropsychopharmacology | volume = 39 | issue = 3 | pages = 638–50 | year = 2014 | pmid = 24022672 | doi = 10.1038/npp.2013.243 | pmc=3895241}}
15. ^{{cite journal | vauthors = Yang YJ, Li YK, Wang W, Wan JG, Yu B, Wang MZ, Hu B | title = Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia | journal = Pharmacol. Biochem. Behav. | volume = 122 | issue = | pages = 30–6 | year = 2014 | pmid = 24662915 | doi = 10.1016/j.pbb.2014.03.013 | url = http://linkinghub.elsevier.com/retrieve/pii/S0091-3057(14)00083-5}}
16. ^{{cite journal | vauthors = Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, Mori S, Ross CA, Ye K, Duan W | title = Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease | journal = Hum. Mol. Genet. | volume = 22 | issue = 12 | pages = 2462–70 | year = 2013 | pmid = 23446639 | pmc = 3658168 | doi = 10.1093/hmg/ddt098 | url = http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=23446639}}
17. ^{{cite journal | vauthors = Korkmaz OT, Aytan N, Carreras I, Choi JK, Kowall NW, Jenkins BG, Dedeoglu A | title = 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis | journal = Neurosci. Lett. | volume = 566 | issue = | pages = 286–91 | year = 2014 | pmid = 24637017 | pmc = 5906793 | doi = 10.1016/j.neulet.2014.02.058 | url = http://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00171-2}}
18. ^{{cite journal | vauthors = Wu CH, Hung TH, Chen CC, Ke CH, Lee CY, Wang PY, Chen SF | title = Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling | journal = PLoS ONE | volume = 9 | issue = 11 | pages = e113397 | year = 2014 | pmid = 25415296 | pmc = 4240709 | doi = 10.1371/journal.pone.0113397 | url = http://dx.plos.org/10.1371/journal.pone.0113397}}
19. ^{{cite journal | vauthors = Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H | title = 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats | journal = J. Mol. Histol. | volume = 45 | issue = 2 | pages = 129–40 | year = 2014 | pmid = 24045895 | doi = 10.1007/s10735-013-9539-y }}
20. ^{{cite journal | vauthors = Uluc K, Kendigelen P, Fidan E, Zhang L, Chanana V, Kintner D, Akture E, Song C, Ye K, Sun D, Ferrazzano P, Cengiz P | title = TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia | journal = CNS Neurol Disord Drug Targets | volume = 12 | issue = 3 | pages = 360–70 | year = 2013 | pmid = 23469848 | pmc = 3674109 | doi = 10.2174/18715273113129990061| url = http://www.eurekaselect.com/109919/article}}
21. ^{{cite journal | vauthors = Tian M, Zeng Y, Hu Y, Yuan X, Liu S, Li J, Lu P, Sun Y, Gao L, Fu D, Li Y, Wang S, McClintock SM | title = 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome | journal = Neuropharmacology | volume = 89 | issue = | pages = 43–53 | year = 2015 | pmid = 25229717 | doi = 10.1016/j.neuropharm.2014.09.006 | url = http://linkinghub.elsevier.com/retrieve/pii/S0028-3908(14)00313-X}}
22. ^{{cite journal | vauthors = Johnson RA, Lam M, Punzo AM, Li H, Lin BR, Ye K, Mitchell GS, Chang Q | title = 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome | journal = J. Appl. Physiol. | volume = 112 | issue = 5 | pages = 704–10 | year = 2012 | pmid = 22194327 | pmc = 3643819 | doi = 10.1152/japplphysiol.01361.2011 | url = http://jap.physiology.org/cgi/pmidlookup?view=long&pmid=22194327}}
23. ^{{cite journal | vauthors = Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q | title = 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats | journal = J. Neurochem. | volume = 122 | issue = 4 | pages = 800–11 | year = 2012 | pmid = 22694088 | doi = 10.1111/j.1471-4159.2012.07830.x }}
24. ^{{cite journal | vauthors = Bollen E, Vanmierlo T, Akkerman S, Wouters C, Steinbusch HM, Prickaerts J | title = 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice | journal = Behav. Brain Res. | volume = 257 | issue = | pages = 8–12 | year = 2013 | pmid = 24070857 | doi = 10.1016/j.bbr.2013.09.029 | url = http://linkinghub.elsevier.com/retrieve/pii/S0166-4328(13)00579-2}}
25. ^{{cite journal | vauthors = Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ | title = Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning | journal = Am J Psychiatry | volume = 168 | issue = 2 | pages = 163–72 | year = 2011 | pmid = 21123312 | pmc = 3770732 | doi = 10.1176/appi.ajp.2010.10030326 | url = http://psychiatryonline.org/doi/abs/10.1176/appi.ajp.2010.10030326?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}
26. ^{{cite journal|last1=Foti|first1=Mario|last2=Piattelli|first2=Mario|last3=Baratta|first3=Maria Tiziana|last4=Ruberto|first4=Giuseppe|title=Flavonoids, Coumarins, and Cinnamic Acids as Antioxidants in a Micellar System. Structure−Activity Relationship†|journal=Journal of Agricultural and Food Chemistry|volume=44|issue=2|year=1996|pages=497–501|issn=0021-8561|doi=10.1021/jf950378u}}
27. ^{{cite journal | vauthors = Chen J, Chua KW, Chua CC, Yu H, Pei A, Chua BH, Hamdy RC, Xu X, Liu CF | title = Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity | journal = Neurosci. Lett. | volume = 499 | issue = 3 | pages = 181–5 | year = 2011 | pmid = 21651962 | doi = 10.1016/j.neulet.2011.05.054 | url = http://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)00680-X}}
28. ^{{cite journal | vauthors = Han X, Zhu S, Wang B, Chen L, Li R, Yao W, Qu Z | title = Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity | journal = Neurochem. Int. | volume = 64 | issue = | pages = 18–23 | year = 2014 | pmid = 24220540 | doi = 10.1016/j.neuint.2013.10.018 | url = http://linkinghub.elsevier.com/retrieve/pii/S0197-0186(13)00291-X}}
29. ^{{cite journal | vauthors = Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Chang WY, You HJ, Lee IK, Kim BJ, Kang SS, Hyun JW | title = Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity | journal = Biol. Pharm. Bull. | volume = 32 | issue = 2 | pages = 166–71 | year = 2009 | pmid = 19182370 | doi = 10.1248/bpb.32.166| url = http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/32.166?from=PubMed}}
30. ^{{cite journal | vauthors = Ren Q, Zhang JC, Ma M, Fujita Y, Wu J, Hashimoto K | title = 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine | journal = Psychopharmacology | volume = 231 | issue = 1 | pages = 159–66 | year = 2014 | pmid = 23934209 | doi = 10.1007/s00213-013-3221-7 }}
31. ^{{cite journal | vauthors = Boltaev U, Meyer Y, Tolibzoda F, Jacques T, Gassaway M, Xu Q, Wagner F, Zhang YL, Palmer M, Holson E, Sames D | title = Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists | journal = Sci Signal | volume = 10 | issue = 493 | pages = eaal1670| year = 2017 | pmid = 28831019 | doi = 10.1126/scisignal.aal1670 | url = }}
32. ^{{cite journal | vauthors = Todd D, Gowers I, Dowler SJ, Wall MD, McAllister G, Fischer DF, Dijkstra S, Fratantoni SA, van de Bospoort R, Veenman-Koepke J, Flynn G, Arjomand J, Dominguez C, Munoz-Sanjuan I, Wityak J, Bard JA | title = A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease | journal = PLoS ONE | volume = 9 | issue = 2 | pages = e87923 | year = 2014 | pmid = 24503862 | pmc = 3913682 | doi = 10.1371/journal.pone.0087923 | url = }}
33. ^{{cite journal | vauthors = Kao YC, Zhou C, Sherman M, Laughton CA, Chen S | title = Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study | journal = Environ. Health Perspect. | volume = 106 | issue = 2 | pages = 85–92 | year = 1998 | pmid = 9435150 | pmc = 1533021 | doi = 10.1289/ehp.9810685| url = }}
34. ^{{cite journal|last1=Le Bail|first1=J.C|last2=Laroche|first2=T|last3=Marre-Fournier|first3=F|last4=Habrioux|first4=G|title=Aromatase and 17β-hydroxysteroid dehydrogenase inhibition by flavonoids|journal=Cancer Letters|volume=133|issue=1|year=1998|pages=101–106|issn=0304-3835|doi=10.1016/S0304-3835(98)00211-0|pmid=9929167}}
35. ^{{cite journal | vauthors = Le Bail JC, Varnat F, Nicolas JC, Habrioux G | title = Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids | journal = Cancer Lett. | volume = 130 | issue = 1–2 | pages = 209–16 | year = 1998 | pmid = 9751276 | doi = 10.1016/S0304-3835(98)00141-4| url = http://linkinghub.elsevier.com/retrieve/pii/S0304-3835(98)00141-4}}
36. ^{{cite journal | vauthors = Pouget C, Lauthier F, Simon A, Fagnere C, Basly JP, Delage C, Chulia AJ | title = Flavonoids: structural requirements for antiproliferative activity on breast cancer cells | journal = Bioorg. Med. Chem. Lett. | volume = 11 | issue = 24 | pages = 3095–7 | year = 2001 | pmid = 11720850 | doi = 10.1016/S0960-894X(01)00617-5| url = http://linkinghub.elsevier.com/retrieve/pii/S0960894X01006175}}
37. ^1 {{cite journal|last1=Liu|first1=Xia|last2=Chan|first2=Chi-Bun|last3=Jang|first3=Sung-Wuk|last4=Pradoldej|first4=Sompol|last5=Huang|first5=Junjian|last6=He|first6=Kunyan|last7=Phun|first7=Lien H.|last8=France|first8=Stefan|last9=Xiao|first9=Ge|last10=Jia|first10=Yonghui|last11=Luo|first11=Hongbo R.|last12=Ye|first12=Keqiang|title=A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect|journal=Journal of Medicinal Chemistry|volume=53|issue=23|year=2010|pages=8274–8286|issn=0022-2623|doi=10.1021/jm101206p|pmid=21073191|pmc=3150605}}
{{Flavones}}{{Antioxidants}}{{Phytoestrogens}}{{Growth factor receptor modulators}}{{Estrogen receptor modulators}}{{DEFAULTSORT:Dihydroxyflavone, 7,8-}}

9 : Antidepressants|Antioxidants|Aromatase inhibitors|Flavones|Neuroprotective agents|Nootropics|Phytoestrogens|Steroid sulfotransferase inhibitors|TrkB agonists
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/26 0:30:43