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词条 A-1,6-mannosyl-glycoprotein 6-b-N-acetylglucosaminyltransferase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
| EC_number = 2.4.1.155
| CAS_number = 83588-90-3
| IUBMB_EC_number = 2/4/1/155
| GO_code =
| image =
| width =
| caption =
}}Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase ({{EC number|2.4.1.155}}, N-acetylglucosaminyltransferase V, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase, UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, GnTV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References

1. ^{{cite journal | vauthors = Cummings RD, Trowbridge IS, Kornfeld S | title = A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase | journal = The Journal of Biological Chemistry | volume = 257 | issue = 22 | pages = 13421–7 | date = November 1982 | pmid = 6216250 }}
2. ^{{cite journal | vauthors = Hindsgaul O, Tahir SH, Srivastava OP, Pierce M | title = The trisaccharide beta-D-GlcpNAc-(1----2)-alpha-D-Manp-(1----6)-beta-D-Manp, as its 8-methoxycarbonyloctyl glycoside, is an acceptor selective for N-acetylglucosaminyltransferase V | journal = Carbohydrate Research | volume = 173 | issue = 2 | pages = 263–72 | date = March 1988 | pmid = 2834054 | doi = 10.1016/s0008-6215(00)90822-x }}

External links

  • {{MeshName|Alpha-1,6-mannosyl-glycoprotein+6-beta-N-acetylglucosaminyltransferase}}
{{Glycosyltransferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 2.4.1

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