| 词条 | AC927 |
| 释义 |
| IUPAC_name = 1-(2-phenylethyl)piperidine | image = AC927.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 332-14-9 | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 9141 | C=13 | H=19 | N=1 | molecular_weight = 189.30 g/mol }}AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.[1] AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.[1] References1. ^1 {{cite journal |vauthors=Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A | title = Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies | journal = Eur. Neuropsychopharmacol. | volume = 18 | issue = 12 | pages = 871–81 | year = 2008 | month = | pmid = | doi = 10.1016/j.euroneuro.2008.07.006 | pmc = 2688716 }} {{Sigma receptor modulators}} 1 : Piperidines |
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