| 词条 | Aceglutamide |
| 释义 |
| ImageFile = Aceglutamide.svg | ImageFile_Ref = {{chemboximage|correct|??}} | ImageSize = 160 | ImageName = Stereo, skeletal formula of aceglutamide (S) | IUPACName = 2-(Acetylamino)-glutaramidic acid | OtherNames = KW-110; α-N-Acetylglutamine;[1] aceglutamide aluminum (JAN, USAN) |Section1={{Chembox Identifiers | CASNo = 5817-09-4 | CASNo_Ref = {{cascite|correct|??}} | CASNo_Comment = R/S | CASNo1 =161579-61-9 | CASNo1_Comment =R | CASNo2 =2490-97-3 | CASNo2_Comment =S | PubChem = 25561 | PubChem_Comment = R/S | PubChem1 = 444019 | PubChem1_Comment = R | PubChem2 = 182230 | PubChem2_Comment = S | ChemSpiderID = 23836 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Comment = R/S | ChemSpiderID1 = 392045 | ChemSpiderID1_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID1_Comment = R | ChemSpiderID2 = 158492 | ChemSpiderID2_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID2_Comment = S | UNII = 01J18G9G97 | UNII_Ref = {{fdacite|correct|FDA}} | EINECS = 219-647-7 | DrugBank = DB04167 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | KEGG = D07063 | KEGG_Ref = {{keggcite|correct|kegg}} | MeSHName = aceglutamide | SMILES = CC(=O)NC(CCC(N)=O)C(O)=O | StdInChI = 1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13) | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = KSMRODHGGIIXDV-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} }} |Section2={{Chembox Properties | C=7 | H=12 | N=2 | O=4 | Appearance = White crystals | MeltingPtC = 197 }} |Section3={{Chembox Related | OtherFunction_label = alkanoic acids | OtherFunction = {{unbulleted list|N-Acetylaspartic acid|N-Acetylglutamic acid|Citrulline|Pivagabine}} | OtherCompounds = {{unbulleted list|Bromisoval|Carbromal}} }} }}Aceglutamide (brand name Neuramina), or aceglutamide aluminum (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan.[1][2][3][4] It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain.[5] Aceglutamide functions as a prodrug to glutamine with improved potency and stability.[5] Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers.[6][7][8][9] Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition.[10][11][12] The drug has shown neuroprotective effects in an animal model of cerebral ischemia.[5] See also
References1. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA3|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=3–}} {{Nootropics}}{{Stimulants}}{{Drugs for peptic ulcer and GORD}}{{Antacids}}{{Glutamatergics}}2. ^{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA6|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=6–}} 3. ^{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA35|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=35–}} 4. ^{{cite book|author1=I.K. Morton|author2=Judith M. Hall|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA3|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=3–}} 5. ^1 2 {{cite journal|last1=Zhang|first1=Rui|last2=Yang|first2=Nan|last3=Ji|first3=Chao|last4=Zheng|first4=Ji|last5=Liang|first5=Zhen|last6=Hou|first6=Chun-Ying|last7=Liu|first7=Yan-Yong|last8=Zuo|first8=Ping-Ping|title=Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion|journal=Restorative Neurology and Neuroscience|volume=33|issue=5|year=2015|pages=741–759|issn=0922-6028|doi=10.3233/RNN-150509}} 6. ^{{cite journal | pmid = 7095654 | year = 1982 | last1 = Ito | first1 = M | last2 = Yokochi | first2 = E | last3 = Kobayashi | first3 = C | last4 = Suzuki | first4 = Y | title = Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl) | volume = 79 | issue = 4 | pages = 327–34 | journal = Nihon yakurigaku zasshi. Folia pharmacologica Japonica}} 7. ^{{cite journal | title = Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW-110) and related compounds on gastric erosion and motility in stressed animals |author1=Harada, Masatoshi |author2=Yano, Shingo | journal = Oyo Yakuri | year = 1974 | volume = 8 | issue = 1 | pages = 1–6}} 8. ^{{cite journal | pmid = 1790087 | year = 1991 | last1 = Varas Lorenzo | first1 = MJ | last2 = López Martínez | first2 = A | last3 = Gordillo Bernal | first3 = J | last4 = Mundet Surroca | first4 = J | title = Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer | volume = 80 | issue = 2 | pages = 91–4 | journal = Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva}} 9. ^{{cite journal | pmid = 7098147 | year = 1982 | last1 = Tanaka | first1 = H | last2 = Shuto | first2 = K | last3 = Marumo | first3 = H | title = Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats | volume = 32 | issue = 2 | pages = 307–13 | journal = Japanese journal of pharmacology | doi=10.1254/jjp.32.307}} 10. ^{{cite journal |author1=Lopez-Pedrosa Jose M |author2=Manzano Manuel |author3=Baxter Jeffrey H |author4=Rueda Ricardo | journal = Digestive Diseases and Sciences | year = 2007 | volume = 52 | issue = 3 | pages = 650–658 | doi = 10.1007/s10620-006-9500-y | pmid = 17253138 | title = N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs}} 11. ^{{cite patent|JP|10101576}} 12. ^{{cite patent|US|2003099722}} 6 : Acetamides|Amino acid derivatives|Drugs acting on the gastrointestinal system and metabolism|Nootropics|Prodrugs|Stimulants |
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