| 词条 | Aderbasib |
| 释义 |
| IUPAC_name = methyl (6S,7S)-7-(hydroxycarbamoyl)-6-[(4-phenyl-1-piperazinyl)carbonyl]-5-azaspiro[2.5]octane-5-carboxylate | image = Aderbasib.svg | alt = Skeletal formula of aderbasib | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Investigational | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | smiles = COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N3CCN(CC3)C4=CC=CC=C4)C(=O)NO | StdInChI = 1S/C21H28N4O5/c1-30-20(28)25-14-21(7-8-21)13-16(18(26)22-29)17(25)19(27)24-11-9-23(10-12-24)15-5-3-2-4-6-15/h2-6,16-17,29H,7-14H2,1H3,(H,22,26)/t16-,17-/m0/s1 | StdInChIKey = DJXMSZSZEIKLQZ-IRXDYDNUSA-N | CAS_number = 791828-58-5 | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = 16070111 | ChEMBL = 1376060 | KEGG = D09320 | UNII = V9YL6NEJ3G | DrugBank = | ChemSpiderID = 17229620 | C=21|H=28|N=4|O=5 | molecular_weight = 416.47 g·mol−1 }}Aderbasib (codenamed INCB7839) is a sheddase inhibitor that may suppress tumor cell proliferation.[1] Acting on multiple receptor classes and subclasses, aderbasib is observed to regulate the tumor necrosis factor of cancer cells.[2] Aderbasib was being developed by Incyte as a potential adjunctive treatment for metastatic breast cancer. Development was halted in 2011 after positive findings from Phase II trials were contradicted by further research.[3][4] References1. ^{{cite web|url=http://www.ama-assn.org/resources/doc/usan/aderbasib.pdf|title=STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL|publisher=Ama-assn.org|accessdate=2012-10-13}} 2. ^{{cite web|url=http://www.medkoo.com/Anticancer-trials/Aderbasib.htm |title=Aderbasib | CAS#791828-58-5 |publisher=MedKoo |date= |accessdate=2012-10-13}} 3. ^{{cite web |url=http://phx.corporate-ir.net/External.File?item=UGFyZW50SUQ9NDQwNjgzfENoaWxkSUQ9NDYyNTAzfFR5cGU9MQ==&t=1 |title=UBS 2011 Global Life Sciences Conference |author=Incyte |date=2011-09-19 |accessdate=2013-02-13}} 4. ^{{cite press release |url=http://www.thestreet.com/story/11290594/1/incyte-reports-third-quarter-2011-financial-results-and-provides-update-on-key-clinical-programs.html |title=Incyte Reports Third Quarter 2011 Financial Results And Provides Update On Key Clinical Programs |date=2011-10-27 |publisher=BusinessWire |accessdate=2013-02-13}} External links
1 : Chemotherapy |
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