| 词条 | Adozelesin |
| 释义 |
| ImageFile = Adozelesin.svg | ImageAlt = | IUPACName = | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 110314-48-2 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 6N3M4XJR2V | KEGG = D02773 | PubChem = 357194 | ChEMBL = 35493 | SMILES =CC1=CNC2=C1C34CC3CN(C4=CC2=O)C(=O)C5=CC6=C(N5)C=CC(=C6)NC(=O)C7=CC8=CC=CC=C8O7 | ChemSpiderID = 317091 | InChI = 1/C30H22N4O4/c1-15-13-31-27-22(35)11-25-30(26(15)27)12-18(30)14-34(25)29(37)21-9-17-8-19(6-7-20(17)33-21)32-28(36)24-10-16-4-2-3-5-23(16)38-24/h2-11,13,18,31,33H,12,14H2,1H3,(H,32,36) | InChIKey = BYRVKDUQDLJUBX-UHFFFAOYAA | StdInChI = 1S/C30H22N4O4/c1-15-13-31-27-22(35)11-25-30(26(15)27)12-18(30)14-34(25)29(37)21-9-17-8-19(6-7-20(17)33-21)32-28(36)24-10-16-4-2-3-5-23(16)38-24/h2-11,13,18,31,33H,12,14H2,1H3,(H,32,36) | StdInChIKey = BYRVKDUQDLJUBX-UHFFFAOYSA-N }} |Section2={{Chembox Properties | C=30 | H=22 | N=4 | O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Adozelesin is an experimental antitumor drug of the duocarmycin class.[1] It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth.[2] References1. ^{{cite journal|pmid=11325853|year=2001|last1=Wang|first1=Y|last2=Beerman|first2=TA|last3=Kowalski|first3=D|title=Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants|volume=61|issue=9|pages=3787–94|journal=Cancer Research}} {{antineoplastic-drug-stub}}2. ^{{cite journal|last1=Liu|first1=J.-S.|last2=Kuo|first2=S.-R.|last3=McHugh|first3=M. M.|last4=Beerman|first4=T. A.|last5=Melendy|first5=T.|title=Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation|journal=Journal of Biological Chemistry|date=14 January 2000|volume=275|issue=2|pages=1391–1397|doi=10.1074/jbc.275.2.1391}} 1 : Experimental cancer drugs |
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