| 词条 | Alazopeptin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 457805069 | IUPAC_name = 6-diazo-26-diazo-5-oxo-2-[(prop-2-en-1-yl)amino]hexanamido5-oxohexanoic acid | image = alazopeptin.png | alt = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 1397-84-8 | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = 5486654 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 92957 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 16735646 | C=15 | H=20 | N=6 | O=5 | molecular_weight = 364.36 g/mol | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H20N6O5/c1-2-7-18-12(5-3-10(22)8-19-16)14(24)21-13(15(25)26)6-4-11(23)9-20-17/h2,8-9,12-13,18H,1,3-7H2,(H2-2,21,22,23,24,25,26)/b10-8-,11-9- | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = RCQIFJCPIWRTAF-WGEIWTTOSA-N | smiles = C=CCNC(CCC(=C[N+]#N)[O-])C(=O)NC(CCC(=C[N+]#N)[O-])C(=O)O }} Alazopeptin is an antibiotic, with moderate anti-trypanosomal.[1] and antitumor activity.[2] It was originally isolated from Streptomyces griseoplanus, sourced from soil near Williamsburg, Iowa.[3] It is still largely produced via fermentation broths of that organism. References1. ^{{cite journal|last1=Ishiyama|first1=Aki|last2=Otoguro|first2=Kazuhiko|last3=Namatame|first3=Miyuki|last4=Nishihara|first4=Aki|last5=Furusawa|first5=Toshiaki|last6=Masuma|first6=Rokuro|last7=Shiomi|first7=Kazuro|last8=Takahashi|first8=Yoko|last9=Ichimura|first9=Michio|last10=Yamada|first10=Haruki|last11=Ōmura|first11=Satoshi|title=In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin|journal=The Journal of Antibiotics|volume=61|issue=10|year=2008|pages=627–632|issn=0021-8820|doi=10.1038/ja.2008.83}} {{antineoplastic-drug-stub}}2. ^{{cite journal|last1=Hata|first1=Toju|last2=Umezawa|first2=Iwao|last3=Iwai|first3=Yuzuru|last4=Katagiri|first4=Mlchiko|last5=Awaya|first5=Juichi|last6=Komiyama|first6=Kanki|last7=Oiwa|first7=Ruiko|last8=Atsumi|first8=Kiyoo|title=STUDIES ON THE ANTITUMOR ACTIVITY OF AN ALAZOPEPTIN ISOLATED FROM A NEW STRAIN OF STREPTOMYCES|journal=The Journal of Antibiotics|volume=26|issue=3|year=1973|pages=181–183|issn=0021-8820|doi=10.7164/antibiotics.26.181}} 3. ^{{cite journal |vauthors=Patterson EL, Johnson BL, DeVoe SE, Bohonos N |title=Structure of the antitumor antibiotic alazopeptin |journal=Antimicrob Agents Chemother |volume=5 |issue= |pages=115–8 |year=1965 |pmid=5883414 }} 3 : Antibiotics|Allyl compounds|Diazo compounds |
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