Albuquerque is a common Portuguese surname, which may refer to:

• Afonso de Albuquerque (1453–1515), a Portuguese fidalgo and naval general officer
• Cássio Albuquerque dos Anjos (born 1980), a Brazilian goalkeeper
• Filipe Albuquerque (born 1985), a Portuguese race car driver
• João Pessoa Cavalcânti de Albuquerque (1878–1930), the governor of Paraíba, Brazil between 1928 and 1930
• Joaquim Arcoverde de Albuquerque Cavalcanti (1850–1930), the first cardinal to be born in the Americas
• Joaquim Augusto Mouzinho de Albuquerque (1855–1902), a Portuguese soldier
• José Albuquerque (born 1975), a Brazilian boxer
• Luís da Silva Mouzinho de Albuquerque (1792–1865), a Portuguese military officer, engineer, poet, scientist and politician
• Marcos Venâncio de Albuquerque (born 1980), Brazilian footballer
• Mike de Albuquerque (born 1947), an English musician
• Oscar Albuquerque (born 1954), a former Canadian soccer midfielder
• Renato de Albuquerque, a Brazilian civil engineer and entrepreneur in the construction and real state businesses
• Glasner da Silva Albuquerque, known as Esquerdinha Brazilian footballer

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