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词条 Alcohol dehydrogenase (nicotinoprotein)
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Alcohol dehydrogenase (nicotinoprotein)
| EC_number = 1.1.99.36
| CAS_number =
| IUBMB_EC_number = 1/1/99/36
| GO_code =
| image =
| width =
| caption =
}}Alcohol dehydrogenase (nicotinoprotein) ({{EC number|1.1.99.36}}, NDMA-dependent alcohol dehydrogenase, nicotinoprotein alcohol dehydrogenase, np-ADH, ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name ethanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

ethanol + acceptor acetaldehyde + reduced acceptor

This enzyme contains Zn2+.

References

1. ^{{cite journal | vauthors = Van Ophem PW, Van Beeumen J, Duine JA | title = Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica | journal = European Journal of Biochemistry | volume = 212 | issue = 3 | pages = 819–26 | date = March 1993 | pmid = 8385013 | doi = 10.1111/j.1432-1033.1993.tb17723.x }}
2. ^{{cite journal | vauthors = Piersma SR, Visser AJ, de Vries S, Duine JA | title = Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase | journal = Biochemistry | volume = 37 | issue = 9 | pages = 3068–77 | date = March 1998 | pmid = 9485460 | doi = 10.1021/bi972115u }}
3. ^{{cite journal | vauthors = Schenkels P, Duine JA | title = Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes | journal = Microbiology | volume = 146 ( Pt 4) | issue = 4 | pages = 775–85 | date = April 2000 | pmid = 10784035 | doi = 10.1099/00221287-146-4-775 }}
4. ^{{cite journal | vauthors = Piersma SR, Norin A, de Vries S, Jörnvall H, Duine JA | title = Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site | journal = Journal of Protein Chemistry | volume = 22 | issue = 5 | pages = 457–61 | date = July 2003 | pmid = 14690248 | doi = 10.1023/b:jopc.0000005461.53788.ee }}
5. ^{{cite journal | vauthors = Norin A, Piersma SR, Duine JA, Jörnvall H | title = Nicotinoprotein (NAD+ -containing) alcohol dehydrogenase: structural relationships and functional interpretations | journal = Cellular and Molecular Life Sciences | volume = 60 | issue = 5 | pages = 999–1006 | date = May 2003 | pmid = 12827287 | doi = 10.1007/s00018-003-3105-9 }}

External links

  • {{MeshName|Alcohol+dehydrogenase+(nicotinoprotein)}}
{{Alcohol oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 1.1.99

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