| 词条 | Ali Shilatifard |
| 释义 |
| name = | native_name = | native_name_lang = | image = Dr. Ali Shilatifard, scientist, biochemist.jpg | image_size = | caption = | birth_date = | birth_place = | death_date = | death_place = | death_cause = | citizenship = | nationality = | fields = | workplaces = {{plainlist|
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}} | known_for = | awards = Elected Fellow of the American Association for the Advancement of Science (AAAS) ASBMB-AMGEN Award[1] | spouse = Laura Shilatifard | children = 4 }} Ali Shilatifard is an American biochemist/molecular biologist, the Robert Francis Furchgott Professor and Chairman of the department of biochemistry and molecular genetics, and the director of the Simpson Query Center for Epigenetics[2] at the Northwestern University Feinberg School of Medicine. He has served as a senior editor for the journal Science, and currently serves as the Editor for Science BiographyShilatifard has said he developed his love of science as a young boy working with and observing his grandfather,[5] a physician/scientist and professor of medicine of the University of Tehran. Shilatifard moved to the United States in 1984 where he began his study of organic chemistry at Kennesaw State University in Georgia. He began to work on his doctoral degree in biochemistry at the University of Georgia, Athens. Shilatifard completed his Ph.D. from the University of Oklahoma where his mentor, Dr. Richard Cummings, had moved his program. As a Jane Coffin Childs Postdoctoral Fellow at the Oklahoma Medical Research Foundation, Shilatifard identified the first function of any of the MLL translocation partners found in leukemia[6] and proposed that transcriptional elongation control is central to leukemia pathogenesis. Shilatifard began his independent lab in the Edward A. Doisy Department of Biochemistry and Molecular Biology at the St. Louis University School of Medicine, where he identified the first histone H3 lysine 4 (H3K4) methylase in Saccharomyces cerevisiae: which he named Set1/COMPASS;[7][8] and defined the pathway of histone H3K4 methylation which is highly conserved from yeast to human.[9][10] Studies from Shilatifard’s laboratory linking epigenetic factors and transcription elongation control to malignancies have provided therapeutic approaches for the treatment of these cancers.[11][12][13] References1. ^{{cite web|last1=Pinholster|first1=Ginger|title=2016 AAAS Fellows Honored for Advancing Science to Serve Society|url=https://www.aaas.org/news/2016-aaas-fellows-honored-advancing-science-serve-society|website=AAAS|publisher=AAAS|accessdate=30 May 2017}} 2. ^{{cite web|title=Northwestern Receives $10 Million for Epigenetics Center|url=https://philanthropynewsdigest.org/news/northwestern-receives-10-million-for-epigenetics-center|website=Philanthropy News Digest|publisher=Foundation Center|accessdate=9 February 2018}} 3. ^{{Cite web|url=http://advances.sciencemag.org/content/editorial-board|title=Editorial Board {{!}} Science Advances|website=advances.sciencemag.org|language=en|access-date=2018-06-27}} 4. ^{{cite journal |last1=Shilatifard |first1=Ali |title=Impactful science as the guiding principle |journal=Science Advances |volume=4 |issue=7 |pages=eaau1696 |pmid=29978047 |pmc=6031368 |year=2018 |doi=10.1126/sciadv.aau1696 }} 5. ^Ali Shilatifard: Discovering the roots of cancer, St. Louis Business Journal, Jul 23, 2006 6. ^{{cite journal| pmid=8596958 | volume=271 | issue=5257 | title=An RNA polymerase II elongation factor encoded by the human ELL gene | date=March 1996 | journal=Science | pages=1873–6 | last1 = Shilatifard | first1 = A | last2 = Lane | first2 = WS | last3 = Jackson | first3 = KW | last4 = Conaway | first4 = RC | last5 = Conaway | first5 = JW | doi=10.1126/science.271.5257.1873| bibcode=1996Sci...271.1873S }} 7. ^{{cite journal | last1 = Miller | first1 = T. |display-authors=et al | year = 2001 | title = COMPASS: a complex of proteins associated with a trithorax-related SET domain protein | url = | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 23| pages = 12902–12907 | doi=10.1073/pnas.231473398| bibcode = 2001PNAS...9812902M | pmc = 60797 }} 8. ^{{cite journal | last1 = Krogan | first1 = N. J. |display-authors=et al | year = 2002| title = COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression | url = | journal = J Biol Chem | volume = 277 | issue = 13| pages = 10753–10755 | doi = 10.1074/jbc.C200023200 }} 9. ^{{cite journal | last1 = Smith | first1 = E. | last2 = Shilatifard | first2 = A. | year = 2010| title = The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes | journal = Mol Cell | volume = 40 | issue = 5| pages = 689–701 | doi = 10.1016/j.molcel.2010.11.031 | pmid = 21145479 | pmc=3037032}} 10. ^{{cite journal | last1 = Lee | first1 = J. S. |display-authors=et al | year = 2007| title = Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS | url = | journal = Cell | volume = 131 | issue = 6| pages = 1084–1096 | doi = 10.1016/j.cell.2007.09.046 }} 11. ^{{cite journal |doi=10.1038/nm.4296 |pmid=28263307 |title=Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas |journal=Nature Medicine |volume=23 |issue=4 |pages=493 |year=2017 |last1=Piunti |first1=Andrea |last2=Hashizume |first2=Rintaro |last3=Morgan |first3=Marc A |last4=Bartom |first4=Elizabeth T |last5=Horbinski |first5=Craig M |last6=Marshall |first6=Stacy A |last7=Rendleman |first7=Emily J |last8=Ma |first8=Quanhong |last9=Takahashi |first9=Yoh-hei |last10=Woodfin |first10=Ashley R |last11=Misharin |first11=Alexander V |last12=Abshiru |first12=Nebiyu A |last13=Lulla |first13=Rishi R |last14=Saratsis |first14=Amanda M |last15=Kelleher |first15=Neil L |last16=James |first16=C David |last17=Shilatifard |first17=Ali |pmc=5667640}} 12. ^{{cite journal |doi=10.1016/j.cell.2016.12.011 |pmid=28065413 |pmc=5351781 |title=Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia |journal=Cell |volume=168 |issue=1–2 |pages=59–72.e13 |year=2017 |last1=Liang |first1=Kaiwei |last2=Volk |first2=Andrew G |last3=Haug |first3=Jeffrey S |last4=Marshall |first4=Stacy A |last5=Woodfin |first5=Ashley R |last6=Bartom |first6=Elizabeth T |last7=Gilmore |first7=Joshua M |last8=Florens |first8=Laurence |last9=Washburn |first9=Michael P |last10=Sullivan |first10=Kelly D |last11=Espinosa |first11=Joaquin M |last12=Cannova |first12=Joseph |last13=Zhang |first13=Jiwang |last14=Smith |first14=Edwin R |last15=Crispino |first15=John D |last16=Shilatifard |first16=Ali }} 13. ^{{Cite journal|last=Wang|first=Lu|last2=Zhao|first2=Zibo|last3=Ozark|first3=Patrick A.|last4=Fantini|first4=Damiano|last5=Marshall|first5=Stacy A.|last6=Rendleman|first6=Emily J.|last7=Cozzolino|first7=Kira A.|last8=Louis|first8=Nundia|last9=He|first9=Xingyao|date=2018-05-21|title=Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy|journal=Nature Medicine|volume=24|issue=6|pages=758–769|doi=10.1038/s41591-018-0034-6|issn=1546-170X|pmid=29785026|pmc=6055231}} External links
7 : 1966 births|Living people|American biochemists|American molecular biologists|Kennesaw State University alumni|University of Oklahoma alumni|Iranian biochemists |
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