| 词条 | Alkyl-lysophospholipids |
| 释义 |
Alky-lysophospholipids (ALP) are synthetic analogues of lysophosphatidylcholines (LPC), also called lysolecithins. They are synthesized by replacing the acyl-group within the LPC with an alkyl-group.[1] They are in contrast to LPC metabolically very stable.[1][2] They have anti-neoplastic (“anti-cancer”)[1] and immune modulating effects.[2] Their anti-tumor effects are due to modulation of intracellular signalling pathways, inducing apoptosis.[3] It is highly selective, sparing healthy cells.[2] Several like edelfosine, miltefosine and perifosine are under research and development as drugs against cancer and other diseases. References1. ^1 2 {{cite journal|last=Munder|first=PG|author2=Modolell M|author3= Adreesen R|author4= Weltzien HU|author5= Westphal O|title=Lysophosphatidylcholine (Lysolecithin) and its Synthetic Analogues. Immunemodulating and Other Biologic Effects|journal=Springer Seminars in Immunopathology|year=1979|volume=203|pages=187–203}} 2. ^1 2 {{cite journal|last=Houlihan|first=W|author2=Lohmeyer M|author3= Workman P|author4= Cheon SH|title=Phospholipid antitumor agents|journal=Medicinal Research Reviews|year=1995|volume=15|issue=3|pages=157–223|doi=10.1002/med.2610150302|pmid=7658750}} 3. ^{{cite journal|last=van Blitterswijk|first=W|author2=Verheij M|title=Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects|journal=Current Pharmaceutical Design|year=2008|volume=14|issue=21|pages=2061–74|doi=10.2174/138161208785294636|pmid=18691116}} 1 : Experimental cancer drugs |
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