| 词条 | Altemicidin |
| 释义 |
| ImageFile = Altemicidin.svg | ImageSize = 150px | ImageAlt = | IUPACName = (4aR,6S,7R,7aS)-4-carbamoyl-6-hydroxy-2-methyl-7-(2-sulfamoylacetamido)-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[c]pyridine-7-carboxylic acid | OtherNames = |Section1={{Chembox Identifiers | CASNo = 125399-82-8 | PubChem = 11036174 | ChemSpiderID = 9211348 | SMILES = O=S(=O)(N)CC(=O)N[C@@]2(C(=O)O)[C@@H](O)C[C@H]1C(=C/N(C[C@H]12)C)\\C(=O)N | InChI = 1/C13H20N4O7S/c1-17-3-7(11(14)20)6-2-9(18)13(12(21)22,8(6)4-17)16-10(19)5-25(15,23)24/h3,6,8-9,18H,2,4-5H2,1H3,(H2,14,20)(H,16,19)(H,21,22)(H2,15,23,24)/t6-,8+,9-,13+/m0/s1 | InChIKey = VZRFZUPFQKSXPV-VPFIQFBEBF | StdInChI = 1S/C13H20N4O7S/c1-17-3-7(11(14)20)6-2-9(18)13(12(21)22,8(6)4-17)16-10(19)5-25(15,23)24/h3,6,8-9,18H,2,4-5H2,1H3,(H2,14,20)(H,16,19)(H,21,22)(H2,15,23,24)/t6-,8+,9-,13+/m0/s1 | StdInChIKey = VZRFZUPFQKSXPV-VPFIQFBESA-N}} |Section2={{Chembox Properties | Formula = C13H20N4O7S | MolarMass = 376.39 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Altemicidin is monoterpene alkaloid first identified in isolates from marine actinomycetes (specifically Streptomyces sioyaensis) in 1989.[1][2] It may also be produced synthetically.[3][4] Altemicidin displays both acaricidal and antitumor activity.[1] References1. ^1 {{cite journal|last1=Takahashi|first1=Atsushi|last2=Kurasawa|first2=Shogo|last3=Ikeda|first3=Daishiro|last4=Okami|first4=Yoshiro|last5=Takeuchi|first5=Tomio|title=Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.|journal=The Journal of Antibiotics|volume=42|issue=11|year=1989|pages=1556–1561|issn=0021-8820|doi=10.7164/antibiotics.42.1556}} {{alkaloid-stub}}2. ^{{cite journal|last1=Takahashi|first1=Atsushi|last2=Ikeda|first2=Daishiro|last3=Nakamura|first3=Hikaru|last4=Naganawa|first4=Hiroshi|last5=Kurasawa|first5=Shogo|last6=Okami|first6=Yoshiro|last7=Takeuchi|first7=Tomio|last8=Iitaka|first8=Yoichi|title=Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.|journal=The Journal of Antibiotics|volume=42|issue=11|year=1989|pages=1562–1566|issn=0021-8820|doi=10.7164/antibiotics.42.1562}} 3. ^{{cite journal|last1=Kende|first1=Andrew S.|last2=Liu|first2=Kun|last3=Jos Brands|first3=K. M.|title=Total Synthesis of (-)-Altemicidin: A Novel Exploitation of the Potier-Polonovski Rearrangement|journal=Journal of the American Chemical Society|volume=117|issue=42|year=1995|pages=10597–10598|issn=0002-7863|doi=10.1021/ja00147a032}} 4. ^{{cite journal|last1=Kan|first1=Toshiyuki|last2=Kawamoto|first2=Yuichiro|last3=Asakawa|first3=Tomohiro|last4=Furuta|first4=Takumi|last5=Fukuyama|first5=Tohru|title=Synthetic Studies on Altemicidin: Stereocontrolled Construction of the Core Framework|journal=Organic Letters|volume=10|issue=2|year=2008|pages=169–171|issn=1523-7060|doi=10.1021/ol701940f|pmid=18081299}} 1 : Alkaloids |
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