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| Name = Aminopyrimidine aminohydrolase
| EC_number = 3.5.99.2
| CAS_number = 9024-80-0
| IUBMB_EC_number = 3/5/99/2
| GO_code =
| image =
| width =
| caption =
}}Aminopyrimidine aminohydrolase ({{EC number|3.5.99.2}}, thiaminase, thiaminase II, tenA (gene)) is an enzyme with systematic name 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H2O4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
(2) thiamine + H2O
This enzyme was previously known as thiaminase II.
References
1. ^{{cite journal | vauthors = Fujita A, Nose Y | title = The second type of bacterial thiaminase | journal = The Journal of Vitaminology | volume = 1 | issue = 1 | pages = 1–7 | date = July 1954 | pmid = 13243520 | doi = 10.5925/jnsv1954.1.1 }}
2. ^{{cite journal | title = Purification of thiaminase II | vauthors = Ikehata H |journal = J. Gen. Appl. Microbiol. |year = 1960 |volume = 6 |pages = 30–39 |pmid = |doi=10.2323/jgam.6.30}}
3. ^{{cite journal | vauthors = Toms AV, Haas AL, Park JH, Begley TP, Ealick SE | title = Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II | journal = Biochemistry | volume = 44 | issue = 7 | pages = 2319–29 | date = February 2005 | pmid = 15709744 | doi = 10.1021/bi0478648 }}
4. ^{{cite journal | vauthors = Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF | title = The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism | journal = Acta Crystallographica Section D | volume = 61 | issue = Pt 5 | pages = 589–98 | date = May 2005 | pmid = 15858269 | doi = 10.1107/S0907444905005147 }}
5. ^{{cite journal | vauthors = Jenkins AH, Schyns G, Potot S, Sun G, Begley TP | title = A new thiamin salvage pathway | journal = Nature Chemical Biology | volume = 3 | issue = 8 | pages = 492–7 | date = August 2007 | pmid = 17618314 | doi = 10.1038/nchembio.2007.13 }}
6. ^{{cite journal | vauthors = Jenkins AL, Zhang Y, Ealick SE, Begley TP | title = Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis | journal = Bioorganic Chemistry | volume = 36 | issue = 1 | pages = 29–32 | date = February 2008 | pmid = 18054064 | pmc = 2293645 | doi = 10.1016/j.bioorg.2007.10.005 }}
7. ^{{cite journal | vauthors = French JB, Begley TP, Ealick SE | title = Structure of trifunctional THI20 from yeast | journal = Acta Crystallographica Section D | volume = 67 | issue = Pt 9 | pages = 784–91 | date = September 2011 | pmid = 21904031 | pmc = 3169313 | doi = 10.1107/S0907444911024814 }}
2. ^{{cite journal | title = Purification of thiaminase II | vauthors = Ikehata H |journal = J. Gen. Appl. Microbiol. |year = 1960 |volume = 6 |pages = 30–39 |pmid = |doi=10.2323/jgam.6.30}}
3. ^{{cite journal | vauthors = Toms AV, Haas AL, Park JH, Begley TP, Ealick SE | title = Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II | journal = Biochemistry | volume = 44 | issue = 7 | pages = 2319–29 | date = February 2005 | pmid = 15709744 | doi = 10.1021/bi0478648 }}
4. ^{{cite journal | vauthors = Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF | title = The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism | journal = Acta Crystallographica Section D | volume = 61 | issue = Pt 5 | pages = 589–98 | date = May 2005 | pmid = 15858269 | doi = 10.1107/S0907444905005147 }}
5. ^{{cite journal | vauthors = Jenkins AH, Schyns G, Potot S, Sun G, Begley TP | title = A new thiamin salvage pathway | journal = Nature Chemical Biology | volume = 3 | issue = 8 | pages = 492–7 | date = August 2007 | pmid = 17618314 | doi = 10.1038/nchembio.2007.13 }}
6. ^{{cite journal | vauthors = Jenkins AL, Zhang Y, Ealick SE, Begley TP | title = Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis | journal = Bioorganic Chemistry | volume = 36 | issue = 1 | pages = 29–32 | date = February 2008 | pmid = 18054064 | pmc = 2293645 | doi = 10.1016/j.bioorg.2007.10.005 }}
7. ^{{cite journal | vauthors = French JB, Begley TP, Ealick SE | title = Structure of trifunctional THI20 from yeast | journal = Acta Crystallographica Section D | volume = 67 | issue = Pt 9 | pages = 784–91 | date = September 2011 | pmid = 21904031 | pmc = 3169313 | doi = 10.1107/S0907444911024814 }}
External links
- {{MeshName|Aminopyrimidine+aminohydrolase}}
1 : EC 3.5.99
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