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词条 Osler's node
释义

  1. Causes

  2. Etymology

  3. External links

  4. References

{{distinguish|Janeway lesion}}Osler's nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. Their presence is one definition of Osler's sign.[1]

Causes

Osler's nodes result from the deposition of immune complexes.[2] The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions.

The nodes are commonly indicative of subacute bacterial endocarditis.[3] 10–25% of endocarditis patients will have Osler's nodes.{{Citation needed|date=December 2008}} Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are non-tender.[2]

Osler's nodes can also be seen in

  • Systemic lupus erythematosus
  • Marantic endocarditis
  • Disseminated gonococcal infection
  • Distal to infected arterial catheter

Etymology

Osler's nodes are named after Sir William Osler who described them in the early 20th century.[4][5]

External links

  • Picture of Osler's nodes and Janeway's lesions

References

1. ^{{DorlandsDict|seven/000097190|Osler sign}}
2. ^{{cite journal|last1=Farrior|first1=JB|last2=Silverman|first2=ME|title=A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis|journal=Chest|volume=70|issue=2|pages=239–43|date=August 1976|url=http://journal.publications.chestnet.org/data/Journals/CHEST/20983/239.pdf|format=PDF|pmid=947688|doi=10.1378/chest.70.2.239}}
3. ^{{DorlandsDict|six/000072701|Osler nodes}}
4. ^{{WhoNamedIt|synd|1702}}
5. ^{{cite journal|last=Osler|first=W|title=Chronic infectious endocarditis|journal=Quarterly Journal of Medicine|year=1908–1909|volume=2|pages=219–230|publisher=Oxford}}
{{Eponymous medical signs for circulatory and respiratory systems}}{{med-sign-stub}}

1 : Symptoms and signs: Cardiac

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