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词条 ANKS4B
释义

  1. Model organisms

  2. References

  3. Further reading

Ankyrin repeat and sterile alpha motif domain containing 4B is a protein that in humans is encoded by the ANKS4B gene.[1] The gene is also known as HARP (Harmonin-interacting, ankyrin repeat-containing protein). Ankyrin repeats mediate protein-protein interactions in very diverse families of proteins.[1]

Model organisms

Model organisms have been used in the study of ANKS4B function. A conditional knockout mouse line, called Anks4btm2a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on mutant mice, but no significant abnormalities were observed.[5]

References

1. ^{{cite web | title = Ankyrin repeat and sterile alpha motif domain containing 4B| url = https://www.ncbi.nlm.nih.gov/gene/257629| accessdate = 2011-12-06}}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBWR/dysmorphology/ |title=Dysmorphology data for Anks4b |publisher=Wellcome Trust Sanger Institute}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBWR/salmonella-challenge/ |title=Salmonella infection data for Anks4b |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBWR/citrobacter-challenge/ |title=Citrobacter infection data for Anks4b |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
6. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Anks4b |title=International Knockout Mouse Consortium}}
8. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4433863 |title=Mouse Genome Informatics}}
9. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
10. ^{{cite journal |author =Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
11. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

  • {{Cite journal

| last1 = Johnston | first1 = A. M.
| last2 = Naselli | first2 = G.
| last3 = Niwa | first3 = H.
| last4 = Brodnicki | first4 = T.
| last5 = Harrison | first5 = L. C.
| last6 = Góñez | first6 = L. J.
| doi = 10.1111/j.1365-2443.2004.00776.x
| title = Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues
| journal = Genes to Cells
| volume = 9
| issue = 10
| pages = 967–982
| year = 2004
| pmid = 15461667
| pmc =
}}{{refend}}{{gene-16-stub}}

2 : Human proteins|Genes mutated in mice

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