| 词条 | Anogen |
| 释义 |
name = Yes Biotech Laboratories Ltd. | logo = | type = Private | slogan = | foundation = 1989 | location_city = Mississauga, Ontario | location_country = Canada | area_served = | key_people = George Q. W. Yeh, President| revenue = | industry = Biomedical Engineering | products = Biopharmaceuticals }}Anogen is the trade name of Yes Biotech Laboratories Ltd., a Canadian biopharmaceutical company based in Mississauga, Ontario. Founded in 1989, Anogen-Yes Biotech specializes in developing and manufacturing monoclonal antibodies, recombinant proteins, synthetic bioactive peptides, and Enzyme linked immunosorbent assay (ELISA) kits for research as well as diagnostic and therapeutic use.[1] It is also committed to seeking medical treatment of cancer, autoimmune, inflammatory and cardiovascular diseases by developing antibody-based biopharmaceuticals.[2][3][4][5][6] It has an office in Orlando, Florida, United States, and two research facilities in China, one in Xuzhou and another in Shanghai.[7] Biopharmaceutical developmentsPsoriasisThe company has developed a proprietary technology for topical antibody treatment of various skin conditions.[6] In early 1999, Abcream, the topical treatment of psoriasis and eczema with anti-Interleukin 8 neutralizing antibody, completed a double-blinded, placebo controlled Phase II/III clinical trials. In these studies, 49% to 53.8% of patients achieved a > 60% improvement and 12.9% to 15.3% of patients achieved a > 90% improvement in Psoriasis Area Severity Index (PASI) score after a six-week treatment cycle with Abcream.[8] In 2002, 1452 patients with psoriasis vulgaris had completed for the Phase IV clinical trail. Of 61.91% patients achieved a > 60% improvement and 17.85% of patients achieved a > 90% improvement in PASI score after an eight-week treatment cycle with Abcream. No significant side effect of any kind was observed during and after the treatment.[9] Abcream (registered as Enboke in China) has been approved by State Food and Drug Administration (SFDA) of China for the treatment of psoriasis and eczema in 2003.[10] Cardiovascular diseasesIt has also developed a monoclonal antibody (R813) to human platelet surface glycoprotein IIIa. The Phase I clinical trial has been completed that this antibody effectively inhibits the aggregation of human platelet with less hemorrhagic risk. Both in vitro and in vivo studies suggest its therapeutic potential for treatment of cardiovascular diseases.[11] Alzheimer's diseaseThree anti-Aβ42 monoclonal antibodies (Xuzhou 1, 2 and 3) have been developed in 2011 for early detection and treatment of Alzheimer's Disease.[5] The clinical trials are planned to be completed within two years.[12] Inflammatory diseasesThe company has begun to develop anti-inflammatory therapy with humanized neutralizing monoclonal antibodies to chemokines.[4] References1. ^Industry Canada - Canada's Life Sciences Exporters http://www.ic.gc.ca/app/ccc/srch/nvgt.do?lang=eng&prtl=1&sbPrtl=&estblmntNo=123456267864&profile=cmpltPrfl&profileId=984&app=sold 2. ^{{cite journal |pmid=8237223 |year=1993 |last1=Shi |first1=WK |last2=Ye |first2=QW |last3=Bao |first3=LP |title=Biological characterization of a monoclonal antibody TB 21 against human transforming growth factor-beta 1 |volume=26 |issue=2 |pages=141–50 |journal=Shi Yan Sheng Wu Xue Bao}} 3. ^{{cite journal |pmid=10628836 |year=1999 |last1=Zhu |first1=ZY |last2=Zhong |first2=CP |last3=Xu |first3=WF |last4=Lin |first4=GM |last5=Ye |first5=GQ |last6=Ji |first6=YY |last7=Sun |first7=B |last8=Yeh |first8=M |title=PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response |volume=9 |issue=4 |pages=271–80 |doi=10.1038/sj.cr.7290026 |journal=Cell Research}} 4. ^1 {{cite journal |doi=10.1016/j.intimp.2009.11.005 |title=Humanized monoclonal antibody against the chemokine CXCL-8 (IL-8) effectively prevents acute lung injury |year=2010 |last1=Bao |first1=Zhiyao |last2=Ye |first2=Qingwei |last3=Gong |first3=Wanghua |last4=Xiang |first4=Yi |last5=Wan |first5=Huanying |journal=International Immunopharmacology |volume=10 |issue=2 |pages=259–63 |pmid=19909826}} 5. ^1 {{cite web|url=http://news.huaihai.tv/xuzhounews/showcontent.php?2011/0116/2011-01-16209537.html |title=Therapeutic monoclonal antibody developed in Xuzhou, China for treatment of Alzheimer's disease. |accessdate=2011-04-14 |author=Xuzhou Television |deadurl=yes |archiveurl=https://web.archive.org/web/20120313085603/http://news.huaihai.tv/xuzhounews/showcontent.php?2011%2F0116%2F2011-01-16209537.html |archivedate=2012-03-13 }} 6. ^1 Topical Treatment of Psoriasis Using Neutralizing Antibodies to IL-8 7. ^{{cite web |url=http://www.asiapacific.ca/news/yes-biotech-laboratories-opens-manufacturing-facility-china |title=Yes Biotech Laboratories Opens Manufacturing Facility in China |accessdate=2011-04-14 |author=Asia Pacific Foundation of Canada }} 8. ^Huang Zuo. (2002). "en bo ke zhi liao yin xie bing de xin ji yuan". China Prescription Drug, 5:54-6 9. ^Liu Xiao-Ming, Yang Guo-Ling, Gao Ming-Yang, Yang Chun-Mei, Tan Xue-Jing, Hou Su-Chun, Yu Xiao-Hong. (2003). "en bo ke ru gao zhi liao xun chang xing yin xie bing 172 li lin chuang guan cha". Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine, 4:252-3 10. ^SFDA registered medicine #S20030093 11. ^Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy 12. ^{{cite web|url=http://epaper.cnxz.com.cn/xzrb/html/2011-01/10/content_502421.htm |title=Therapeutic Monoclonal Antibody for Early Detection and Treatment of Alzheimer's Disease Approved by Chinese Academy of Sciences. |accessdate=2011-04-18 |author=Xuzhou Daily |deadurl=yes |archiveurl=https://web.archive.org/web/20110815183920/http://epaper.cnxz.com.cn/xzrb/html/2011-01/10/content_502421.htm |archivedate=2011-08-15 }} External links
6 : Biotechnology companies of Canada|Pharmaceutical companies of Canada|Pharmaceutical companies established in 1989|Companies based in Mississauga|Biotechnology companies established in 1989|1989 establishments in Ontario |
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