| 词条 | Apicidin |
| 释义 |
| ImageFile = Apicidin.svg | ImageSize = 200px | ImageAlt = | IUPACName = (3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 7495 | CASNo = 183506-66-3 | PubChem = 6918328 | ChemSpiderID = 5293532 | SMILES = CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC | InChI = 1/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1 | InChIKey = JWOGUUIOCYMBPV-GMFLJSBRBJ | StdInChI = 1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1 | StdInChIKey = JWOGUUIOCYMBPV-GMFLJSBRSA-N }} |Section2={{Chembox Properties | C=34 | H=49 | N=5 | O=6 | MolarMass = | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Apicidin is a fungal metabolite, as well as a histone deacetylase inhibitor.[1] References1. ^{{cite journal|title=Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin|pmid=11085529 | volume=60 | issue=21|date=November 2000|journal=Cancer Res.|pages=6068–74}} {{HDAC inhibitors}}{{organic-compound-stub}} 1 : Histone deacetylase inhibitors |
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