| 词条 | Apovitellenin-1 |
| 释义 |
| Symbol = Apo-VLDL-II | Name = Apo-VLDL-II | image = | width = | caption = | Pfam = PF05418 | Pfam_clan = | InterPro = IPR008404 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, apovitellenin-1 is a family of proteins found in birds. As part of the avian reproductive effort, large quantities of triglyceride-rich very-low-density lipoprotein (VLDL) particles are transported by receptor-mediated endocytosis into the female germ cells, apovitellenin-1 is a protein component of this VLDL. Although the oocytes are surrounded by a layer of granulosa cells harbouring high levels of active lipoprotein lipase, non-lipolysed VLDL is transported into the yolk. This is because the VLDL particles are protected from lipolysis by apovitellenin-1a, which acts as a potent dimeric lipoprotein lipase inhibitor.[1] Apo-VLDL-II is produced in the liver and secreted into the blood stream when induced by estrogen production in female birds. References1. ^{{cite journal |vauthors=MacLachlan I, Steyrer E, Hermetter A, Nimpf J, Schneider WJ | title = Molecular characterization of quail apolipoprotein very-low-density lipoprotein II: disulphide-bond-mediated dimerization is not essential for inhibition of lipoprotein lipase | journal = Biochem. J. | volume = 317 | issue = 2| pages = 599–604 |date=July 1996 | pmid = 8713091 | pmc = 1217528 | doi = | url = }} {{InterPro content|IPR008404}} 1 : Protein families |
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