词条 | Oxazolidine |
释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 426717757 | Name = Oxazolidine | ImageFile = Structure Oxazolidine.svg | ImageSize = 100px | ImageFile1 = Oxazolidine 3D Balls.png | ImageSize1 = 250px | PIN = Oxazolidine | OtherNames = 1,3-Oxazolidine | Section1 = {{Chembox Identifiers | SMILES = C1COCN1 | CASNo_Ref = {{cascite|correct|??}} | CASNo = 504-76-7 | PubChem = 536683 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 467457 | InChI = 1/C3H7NO/c1-2-5-3-4-1/h4H,1-3H2 | InChIKey = WYNCHZVNFNFDNH-UHFFFAOYAQ | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C3H7NO/c1-2-5-3-4-1/h4H,1-3H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = WYNCHZVNFNFDNH-UHFFFAOYSA-N | RTECS = | MeSHName = C064210 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 50310 }} | Section2 = {{Chembox Properties | Formula = C3H7NO | MolarMass = 73.0938 g/mol | Appearance = }} An oxazolidine is a five-membered ring compound consisting of three carbons, a nitrogen, and an oxygen. The oxygen and NH are the 1 and 3 positions, respectively. In oxazolidine derivatives, there is always a carbon between the oxygen and the nitrogen (or it would be an isoxazolidine).[1][2] All of the carbons in oxazolidines are reduced (compare to oxazole and oxazoline). Some of their derivatives, the oxazolidinediones, are used as anticonvulsants. Oxazolidines were first synthesized over 100 years ago.[3] MonooxazolidinesOxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in Polyurethane and other systems. [4] [5] DioxooxazolidinesOxazolidines where the carbon centers at the 1 and 3 positions are carbonyls are called dioxooxazolidines. Some of these are commercial fungicides including chlozolinate, vinclozolin, and famoxadone.[6] BisoxazolidinesBisoxazolidines are chemical compounds that contain two oxazolidine rings, they are used as performance modifiers in polyurethane coatings and paints. The rings hydrolyze in the presence of moisture to give amine and hydroxyl groups, these can then react with diisocyanates, polyisocyanates and polyurethane prepolymers to form a coating.[7] The use of a bisoxazolidine in a polyurethane systems can prevent the unwanted reaction between isocyanate and moisture resulting in coating defects, as a result of carbon dioxide release. This moisture triggered curing route is preferential to moisture cure. As the ring opening reaction is catalyzed by acids, usually organic acids or anhydrides of carboxylic acids are added in a small amount. The choice of linker between the two oxazolidine rings has a large impact on the performance when used to cure isocyanates. A rigid linker group increases a polyurethanes toughness. A flexible linker group imparts flexibility and increases elongation of a coating. These differences are the reason why bisoxazolidines are used to enhance the performance of polyurethane systems. Usually the rings are linked by esters, urethanes, carbonate or have the two rings fused together. A key intermediate in manufacturing bisoxazolidines is 2-[2-(propan-2-yl)-1,3-oxazolidin-3-yl]ethanol. The hydroxy group on the molecule allows for further reaction with hexamethylene di-isocyanate for example[8][9]. IsoxazolidinesIn an isoxazolidine nitrogen and oxygen occupy positions 1 and 2 in the ring: It is the saturated relative of Isoxazole. See also
References1. ^{{cite web | url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3881507 | title=SID 3881507 -- PubChem Substance Summary | work=The PubChem Project | publisher=United States National Center for Biotechnology Information | accessdate=13 December 2005}} 2. ^Dr Neil G Carter OXAZOLIDINE DILUENTS: REACTING FOR THE ENVIRONMENT {{webarchive|url=https://web.archive.org/web/20010706135437/http://www.chemsoc.org/pdf/gcn/Industrial.pdf |date=2001-07-06 }} Industrial Copolymers Limited 3. ^{{cite journal|doi=10.1021/cr60165a005 | volume=53 | issue=2 | title=The Oxazolidines. | journal=Chemical Reviews | pages=309–352 | last1 = Bergmann | first1 = Ernst D.| year=1953 }} 4. ^{{Cite book|url=https://books.google.com/?id=vlq0UzebgG4C&pg=PA19&lpg=PA19&dq=Oxazolidine+Moisture+Scavengers#v=onepage&q=Oxazolidine%20Moisture%20Scavengers&f=false|title=Handbook Of Coating Additives|last=Florio|first=John J.|last2=Miller|first2=Daniel J.|date=2004-05-26|publisher=CRC Press|isbn=9780824756260|language=en}} 5. ^{{Cite web|url=https://upload.wikimedia.org/wikipedia/commons/8/8a/Nurnberg-Oxazolidine.pdf|title=High Solids Polyurethane Coatings Using Oxazolidine Reactive Diluents|last=Howarth|first=Graham|date=|website=Wikimedia commons|archive-url=|archive-date=|dead-url=|access-date=}} 6. ^{{cite encyclopedia|authors=Franz Müller, Peter Ackermann, Paul Margot|encyclopedia=Ullmann's Encyclopedia of Industrial Chemistry|publisher=Wiley-VCH|location=Weinheim|year=2012|doi=10.1002/14356007.o12_o06|isbn=978-3527306732|chapter=Fungicides, Agricultural, 2. Individual Fungicides}} 7. ^Emission control {{webarchive|url=https://web.archive.org/web/20030106213515/http://www.chemsoc.org/chembytes/ezine/2001/daniels_oct01.htm |date=2003-01-06 }} chembytes e-zine 2001. 8. ^{{Cite web|url=https://echa.europa.eu/registration-dossier/-/registered-dossier/6622/1|title=2-[2-(propan-2-yl)-1,3-oxazolidin-3-yl]ethanol - Registration Dossier - ECHA|website=echa.europa.eu|language=en-GB|access-date=2018-11-14}} 9. ^{{Cite journal|last=Howarth|first=GA|date=July 2003|title=Polyurethanes, polyurethane dispersions and polyureas: Past, present and future|journal=Surface Coatings International Part B: Coatings Transactions|language=en|volume=86|issue=2|pages=111–118|doi=10.1007/bf02699621|issn=1476-4865}} 1 : Oxazolidines |
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