| 词条 | Arbaclofen placarbil |
| 释义 |
| verifiedrevid = | IUPAC_name = (3R)-3-(4-chlorophenyl)-4-[[[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid | image = Arbaclofen placarbil.svg | width = 260 | tradename = | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = N/A | legal_AU = | legal_UK = | legal_US = | legal_status = Development terminated | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 847353-30-4 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | ChEMBL = 2107312 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | PubChem = 11281011 | ChemSpiderID = 9456008 | smiles = CC(C)[C@@H](OC(=O)C(C)C)OC(=O)NC[C@H](CC(=O)O)C1=CC=C(C=C1)Cl | StdInChI = 1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1 | StdInChIKey = JXTAALBWJQJLGN-KSSFIOAISA-N | UNII_Ref = {{fdacite|correct|FDA}} | UNII = | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08861 | ChEMBL_Ref = {{ebicite|correct|EBI}} | C=19 | H=26 | Cl=1 | N=1 | O=6 | molecular_weight = 399.86 g/mol }}Arbaclofen placarbil ({{IPAc-en|ɑːr|ˈ|b|æ|k|l|oʊ|f|ɛ|n|_|p|l|ə|ˈ|k|ɑːr|b|ɪ|l}} {{respell|ar|BAK|loh|fen|_|plə|KAR|bil}}, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1] It is being developed as an addiction medicine to treat alcoholism. [2] See also
References1. ^http://investor.xenoport.com/releasedetail.cfm?ReleaseID=765868 {{Muscle relaxants}}{{Drugs for peptic ulcer and GORD}}{{GABAergics}}{{Channel blockers}}{{gastrointestinal-drug-stub}}{{musculoskeletal-drug-stub}}2. ^ https://inews.co.uk/essentials/news/business/pill-replaces-alcohol-aims-end-middle-class-drinking-epidemic/ 7 : Abandoned drugs|Amino acids|Calcium channel blockers|Chloroarenes|GABA analogues|GABAB receptor agonists|Prodrugs |
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