| 词条 | Ashok Venkitaraman |
| 释义 |
|fetchwikidata=ALL}}Ashok Venkitaraman is a British cancer researcher. He is the Ursula Zoellner Professor of Cancer Research at the University of Cambridge, and the Director of the Medical Research Council Cancer Unit.[1][2] EducationVenkitaraman initially trained in medicine at the Christian Medical College, Vellore, India,[1] before completing his PhD at University College London entitled "The regulation of MHC class 2 gene expression by tumours of the B lymphocyte lineage" supervised by Sir Marc Feldman.[3][4] He undertook post-doctoral research at the MRC Laboratory of Molecular Biology in Cambridge, before becoming a member of its faculty. In 1998 he was elected as the first holder of the Zoellner Professorship.[5] ResearchVenkitaraman is widely recognised for his research into chromosomal instability and cancer, particularly with relation to the breast cancer susceptibility gene, BRCA2.[6] Professor Venkitaraman and his research group were among the first to elucidate the function of BRCA2 in guarding the integrity of human chromosomes, and its role in the development of cancers.[7][8] Combining structural, biophysical, biochemical, genetic and molecular biologic approaches, Venkitaraman’s work helps to explain how BRCA2 monitors the duplication, repair and segregation of genetic information encoded in chromosomes.[9][10][11][12] These insights have subsequently led to the development of new treatments for cancers arising in patients who carry BRCA2 mutations.[8] Venkitaraman’s work on BRCA2 has also provided a conceptual framework for understanding other human genetic diseases in which chromosomal instability is connected with predisposition to cancer.[13] Venkitaraman leads a number of collaborative research initiatives with centres in India.[14] He has worked extensively with industry to help develop drugs against cancer and other diseases. Having completed appointments with Astex Therapeutics, Cambridge Antibody Technology/MedImmune, he is currently the Chair of the Scientific Advisory Board and a Non-Executive Director of Sentinel Oncology.[15] Venkitaraman is also a Fellow of Pembroke College, Cambridge.[16] Honours
References1. ^1 MRC Cancer Unit Professor Ashok Venkitaraman biography {{authority control}}{{DEFAULTSORT:Venkitaraman, Ashok}}2. ^{{Cite book|url=https://doi.org/10.1093/ww/9780199540884.013.41050|title=Venkitaraman, Prof. Ashok|last=|first=|publisher=UK WHOS WHO|year=2017|isbn=|location=|pages=|language=en|doi=10.1093/ww/9780199540884.013.41050}} 3. ^{{Cite journal|last=Ramakrishnan|first=Venkitaraman, Ashok|date=1989|title=The regulation of MHC class 2 gene expression by tumours of the B lymphocyte lineage|url=http://ethos.bl.uk/OrderDetails.do?did=1&uin=uk.bl.ethos.717809}} 4. ^https://spiral.imperial.ac.uk:8443/handle/10044/1/47696 5. ^University of Cambridge announcement 6. ^{{Cite journal | doi = 10.1016/S0092-8674(02)00615-3| title = Cancer Susceptibility and the Functions of BRCA1 and BRCA2| journal = Cell| volume = 108| issue = 2| pages = 171–182| year = 2002| last1 = Venkitaraman | first1 = A. R.| pmid=11832208}} 7. ^University of Cambridge news story 8. ^1 {{cite journal |author=Venkitaraman AR |title=Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2 |journal=Science |volume=343 |issue=6178 |pages=1470–75 |date=March 2014 |pmid=24675954 |doi=10.1126/science.1252230}} 9. ^{{Cite journal | pmid = 9660919| year = 1998| author1 = Patel| first1 = K. J. | authorlink1 = Ketan J. Patel| title = Involvement of Brca2 in DNA repair| journal = Molecular Cell| volume = 1| issue = 3| pages = 347–57| last2 = Yu| first2 = V. P.| last3 = Lee| first3 = H| last4 = Corcoran| first4 = A| last5 = Thistlethwaite| first5 = F. C.| last6 = Evans| first6 = M. J.| last7 = Colledge| first7 = W. H.| last8 = Friedman| first8 = L. S.| last9 = Ponder| first9 = B. A. | authorlink9 = Bruce Ponder| last10 = Venkitaraman| first10 = A. R. | authorlink10 = Ashok Venkitaraman | doi=10.1016/s1097-2765(00)80035-0}} 10. ^{{cite journal |vauthors=Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR |title=Insights into DNA recombination from the structure of a RAD51-BRCA2 complex |journal=Nature |volume=420 |issue=6913 |pages=287–93 |date=November 2002 |pmid=12442171 |doi=10.1038/nature01230}} 11. ^{{cite journal |vauthors=Lomonosov M, Anand S, Sangrithi M, Davies R, Venkitaraman AR |title=Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein |journal=Genes & Development |volume=17 |issue=24 |pages=3017–22 |date=December 2003 |pmid=14681210 |doi=10.1101/gad.279003 |pmc=305253}} 12. ^{{cite journal |vauthors=Daniels MJ, Wang Y, Lee M, Venkitaraman AR |title=Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2 |journal=Science |volume=306 |issue=5697 |pages=876–9 |date=October 2004 |pmid=15375219 |doi=10.1126/science.1102574}} 13. ^{{cite journal |vauthors=Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR |title=Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome |journal=Cell |volume= 121|issue=5697 |pages=887–98 |date=June 2005 |doi=10.1016/j.cell.2005.05.015 |pmid=15960976}} 14. ^Feature in The Hindu 15. ^List of Board members {{webarchive |url=https://web.archive.org/web/20140714185025/http://www.sentineloncology.com/about/sab/ |date=July 14, 2014 }} 16. ^Pembroke College List of Fellows 17. ^Directory of Elected Fellows 18. ^EMBO Membership list 2012 19. ^Cambridge University news story 20. ^Statement on Academy website 7 : Living people|20th-century British biologists|21st-century British biologists|Cancer researchers|Fellows of Pembroke College, Cambridge|Members of the European Molecular Biology Organization|Year of birth missing (living people) |
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