| 词条 | Atagabalin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477351069 | IUPAC_name = [(3S,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid | image = Atagabalin.svg | tradename = | pregnancy_AU = | pregnancy_US = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 223445-75-8 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 593430 | PubChem = 9794485 | ATC_prefix = none | UNII_Ref = {{fdacite|correct|FDA}} | UNII = JT7957Q2FB | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 7970252 | C=10 | H=19 | N=1 | O=2 | molecular_weight = 185.263 g/mol | smiles = C[C@H]1CC(C[C@@H]1C)(CC(=O)O)CN | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H19NO2/c1-7-3-10(6-11,4-8(7)2)5-9(12)13/h7-8H,3-6,11H2,1-2H3,(H,12,13)/t7-,8-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IUVMAUQEZFTTFB-YUMQZZPRSA-N }} Atagabalin (PD-0200,390) is a drug developed by Pfizer and related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2).[1] It was under development as a treatment for insomnia,[2][3][4] but was discontinued following unsatisfactory trial results. See also
References1. ^{{cite journal |vauthors=Blakemore DC, Bryans JS, Carnell P, Carr CL, Chessum NE, Field MJ, Kinsella N, Osborne SA, Warren AN, Williams SC |title=Synthesis and in vivo evaluation of bicyclic gababutins |journal=Bioorganic & Medicinal Chemistry Letters |volume=20 |issue=2 |pages=461–4 |date=January 2010 |pmid=20005103 |doi=10.1016/j.bmcl.2009.11.118 |url=}} {{Hypnotics}}{{Calcium channel blockers}}{{sedative-stub}}2. ^{{cite journal |vauthors=Corrigan B, Feltner DE, Ouellet D, Werth JL, Moton AE, Gibson G |title=Effect of renal impairment on the pharmacokinetics of PD 0200390, a novel ligand for the voltage-gated calcium channel alpha-2-delta subunit |journal=British Journal of Clinical Pharmacology |volume=68 |issue=2 |pages=174–80 |date=August 2009 |pmid=19694735 |pmc=2767279 |doi=10.1111/j.1365-2125.2009.03444.x |url=}} 3. ^{{cite journal |vauthors=Quintero JE, Pomerleau F, Huettl P, Johnson KW, Offord J, Gerhardt GA |title=Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology |journal=Brain Research |volume= 1401|issue= |pages= 1–9|date=May 2011 |pmid=21664606 |doi=10.1016/j.brainres.2011.05.025 |url=|pmc=3197737}} 4. ^{{cite journal |vauthors=Kjellsson MC, Ouellet D, Corrigan B, Karlsson MO |title=Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models |journal=Pharmaceutical Research |volume= 28|issue= 10|pages= 2610–27|date=June 2011 |pmid=21681607 |doi=10.1007/s11095-011-0490-x |url=}} 8 : Abandoned drugs|Amino acids|Calcium channel blockers|GABA analogues|Hypnotics|Pfizer|Pfizer products|Cyclopentanes |
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