| 词条 | Atrolysin C |
| 释义 |
| Name = Atrolysin C | EC_number = 3.4.24.42 | CAS_number = 158886-17-0 | IUBMB_EC_number = 3/4/24/42 | GO_code = | image = | width = | caption = }}Atrolysin C ({{EC number|3.4.24.42}}, Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox). References1. ^{{cite journal | vauthors = Bjarnason JB, Tu AT | title = Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e | journal = Biochemistry | volume = 17 | issue = 16 | pages = 3395–404 | date = August 1978 | pmid = 210790 | doi = 10.1021/bi00609a033 }} 2. ^{{cite journal | vauthors = Fox JW, Campbell R, Beggerly L, Bjarnason JB | title = Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom | journal = European Journal of Biochemistry | volume = 156 | issue = 1 | pages = 65–72 | date = April 1986 | pmid = 3514216 | doi = 10.1111/j.1432-1033.1986.tb09549.x }} 3. ^{{cite journal | vauthors = Bjarnason JB, Fox JW | title = Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom | journal = Biochimica et Biophysica Acta | volume = 911 | issue = 3 | pages = 356–63 | date = February 1987 | pmid = 3101740 | doi = 10.1016/0167-4838(87)90077-x }} 4. ^{{cite journal | vauthors = Mori N, Nikai T, Sugihara H, Tu AT | title = Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom | journal = Archives of Biochemistry and Biophysics | volume = 253 | issue = 1 | pages = 108–21 | date = February 1987 | pmid = 2949699 | doi = 10.1016/0003-9861(87)90643-6 }} 5. ^{{cite journal | vauthors = Shannon JD, Baramova EN, Bjarnason JB, Fox JW | title = Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin | journal = The Journal of Biological Chemistry | volume = 264 | issue = 20 | pages = 11575–83 | date = July 1989 | pmid = 2745407 }} 6. ^{{cite journal | vauthors = Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S | title = Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber | journal = Journal of Biochemistry | volume = 108 | issue = 5 | pages = 711–9 | date = November 1990 | pmid = 2081731 }} External links
1 : EC 3.4.24 |
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