| 词条 | Pancytopenia |
| 释义 |
| name = Pancytopenia | synonyms = | image = | caption = | pronounce = | field = Hematology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets. If only two parameters from the complete blood count are low, the term bicytopenia can be used. The diagnostic approach is the same as for pancytopenia. CausesIatrogenic causes of pancytopenia include chemotherapy for malignancies if the drug or drugs used cause bone marrow suppression. Rarely, drugs (antibiotics, blood pressure medication, heart medication) can cause pancytopenia. The antibiotics Linezolid and Chloramphenicol can cause pancytopenia in some individuals. Rarely, pancytopenia may have other causes, such as mononucleosis, or other viral diseases. Increasingly, HIV is itself a cause of pancytopenia.
MechanismThe mechanism for pancytopenia differ according to the etiology for example in hemophagocytic lymphohistiocytosis (HLH) there is marked inappropriate and ineffective T cell activation that leads to an increased hemophagocytic activity. The T cell activated macrophages engulf erythrocytes, leukocytes, platelets, as well as their progenitor cells. Along with pancytopenia, HLH is characterized by fever, splenomegaly, and hemophagocytosis in bone marrow, liver, or lymph nodes. DiagnosisPancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.
TreatmentTreatment of the underlying cause. Blood transfusion (PRBC) may be indicated according to need. References1. ^{{cite web|title=Analysis of Chronic Radiation Sickness Cases in the Population of the Souther Urals (AD-A286 238)|url=http://www.dtic.mil/cgi-bin/GetTRDoc?Location=U2&doc=GetTRDoc.pdf&AD=ADA286238|publisher=DTIC|accessdate=1 August 2013|vauthors=Kossenko MM, Akleyev AA, Degteva MO, Kozheurov VP, Degtyaryova RC|page=5| date=August 1994 |quote=Complete blood counts, when taken, revealed pancytopenia.}} External links{{Medical resources| DiseasesDB = 24135 | ICD10 = {{ICD10|D|61|9|d|61}} | ICD9 = {{ICD9|284.1}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D010198 }}
2 : Blood disorders|Hematopathology |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。