| 词条 | AVN-101 |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | image = AVN-101.svg | width = 150px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank_Ref = | DrugBank = | ChEMBL = 592752 | ChemSpiderID_Ref = | ChemSpiderID = 24643855 | C=21 | H=24 | N=2 | O= | molecular_weight = | smiles = Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C | StdInChI_Ref = | StdInChIKey_Ref = | StdInChI = 1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 | StdInChIKey = IBUHDDLETPJVGP-UHFFFAOYSA-N | synonyms = }}AVN-101, a close structural analogue of latrepirdine, is a selective 5-HT6 receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders.[1][2][3] As of November 2013, it is in phase II clinical trials for these indications.[2][3][4] See also
References1. ^{{cite journal|last1=V. Ivachtchenko|first1=Alexandre|last2=A. Ivanenkov|first2=Yan|title=Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity|journal=Current Bioactive Compounds|volume=9|issue=1|year=2013|pages=64–100|issn=1573-4072|doi=10.2174/1573407211309010007}} 2. ^1 {{cite journal|last1=Griebel|first1=Guy|last2=Holmes|first2=Andrew|title=50 years of hurdles and hope in anxiolytic drug discovery|journal=Nature Reviews Drug Discovery|volume=12|issue=9|year=2013|pages=667–687|issn=1474-1776|doi=10.1038/nrd4075|pmid=23989795|pmc=4176700}} 3. ^1 {{cite journal|last1=Benhamú|first1=Bellinda|last2=Martín-Fontecha|first2=Mar|last3=Vázquez-Villa|first3=Henar|last4=Pardo|first4=Leonardo|last5=López-Rodríguez|first5=María L.|title=Serotonin 5-HT6Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease|journal=Journal of Medicinal Chemistry|volume=57|issue=17|year=2014|pages=7160–7181|issn=0022-2623|doi=10.1021/jm5003952|pmid=24850589}} 4. ^{{cite web | url = http://adisinsight.springer.com/drugs/800030006 | title = AVN 101 | author = AdisInsight | accessdate = 2015-06-10}} External links
3 : 5-HT6 antagonists|Anxiolytics|Nootropics |
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