请输入您要查询的百科知识:

 

词条 Azerizin
释义

  1. References

  2. External links

Azerizin is claimed to be a proprietary blend of the natural ingredients nicotinamide, azelaic acid, quercetin and curcumin that purportedly combine the anti-inflammatory and antimicrobial properties, along with inhibiting effects on sebum production.{{citation needed|date=June 2014}}

The cascade of events in the inflammatory pathway that result from cell membrane disruption is well documented.[1][2] The release of membrane phospholipids leads to increased production of arachidonic acid which in turn results in elevated leukotriene, prostaglandin and thromboxane production. The ingredients in Azerizin are known to inhibit each of these three major paths of inflammation by blocking or down-regulating pro-inflammatory catalysts at multiple points in the inflammatory cascade, e.g., inhibition of phospholipase, lipooxygenase, COX-2, leukotrienes, thromboxane, prostaglandins, nitric oxide, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF) and interleukin-12.[3][4][5][6]

In addition to these anti-inflammatory actions, the components of Azerizin possess potent antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermis, at least in part attributed to inhibition of microbial cellular protein synthesis.[7][8][9]

Azerizin was developed at Elorac for use as an adjunct in the management of acne vulgaris and rosacea.

References

1. ^{{cite journal|last=Herskowitz|first=Ahvie|author2=Mangano, Dennis T.|title=Inflammatory Cascade: A Final Common Pathway for Perioperative Injury?|journal=Anesthesiology|date=November 1996|volume=85|issue=5|pages=957–960|url=http://journals.lww.com/anesthesiology/fulltext/1996/11000/inflammatory_cascade__a_final_common_pathway_for.1.aspx|doi=10.1097/00000542-199611000-00001}}
2. ^{{cite journal|last=Chainani-wu |first=Nita |title=Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric {sic} (Curcuma longa) |journal=The Journal of Alternate and Complementary Medicine |year=2003 |volume=9 |pages=161–168 |url=https://pinnaclife.com/sites/default/files/research/Curcumin-Safety.pdf |doi=10.1089/107555303321223035 |deadurl=yes |archiveurl=https://web.archive.org/web/20131014162028/https://pinnaclife.com/sites/default/files/research/Curcumin-Safety.pdf |archivedate=2013-10-14 |df= }}
3. ^{{cite journal|last=Chirumbolo|first=S|title=The role of quercetin, flavonols and flavones in modulating inflammatory cell function|journal=Inflamm Allergy Drug Targets|date=Sep 2010|volume=9|issue=4|pages=263–85|doi=10.2174/187152810793358741|pmid=20887269}}
4. ^{{cite journal|last=Fivenson|first=DP|title=The mechanisms of action of nicotinamide and zinc in inflammatory skin disease|journal=Cutis|date=Jan 2006|issue=1 Suppl|pages=5–10}}
5. ^{{cite journal|last=Jurenka|first=Julie S|title=Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research|journal=Alternative Medicine Review|date=2 Nov 2009|volume=14|issue=f2|pages=141–153}}
6. ^{{cite journal|last=Shalita|first=A|author2=Falcon R|author3=Olansky A|author4=Oannotta P|author5=Akhavan A|author6=Day D|author7=Janiga A|author8=Singri P|author9=Kallal J|title=Inflammatory acne management with a novel prescription dietary supplement|journal=Journal of Drugs in Dermatology|year=2012|volume=11}}
7. ^{{cite journal|last=Liu|first=C|author2=Huang H|title=In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System|journal=Chem Pharm Bull|year=2013|volume=61|issue=4|pages=419–425|doi=10.1248/cpb.c12-01043|pmid=23546001}}
8. ^{{cite web|title=azelaic acid - Compound Summary|url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2266|publisher=PubChem}}
9. ^{{cite journal|last=Fitton|first=Andrew|author2=Goa, Karen L|title=Azelaic acid: A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders|journal=Drugs|year=1991|volume=41|pages=780–798|doi=10.2165/00003495-199141050-00007|pmid=1712709|issue=5}}

External links

  • Evidence-based information about herbs, botanicals, supplements, and more, from Memorial Sloan-Kettering Cancer Center
  • Complementary and Alternative Medicine Guide, from the University of Maryland Medical Center
  • Management Options for Rosacea, from the National Rosacea Society
  • Complementary and Alternative Therapies, from the National Psoriasis Foundation

4 : Anti-inflammatory agents|Biologically-based therapies|Antimicrobials|Dietary supplements

随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/11/13 18:24:45