Baldacchino is a surname. Notable people with the surname include:

• Clifford Gatt Baldacchino (born 1988), Maltese footballer
• Francis Baldacchino (1937–2009), Kenyan Roman Catholic bishop
• Godfrey Baldacchino (born 1960), Maltese-Canadian social scientist
• Joseph Baldacchino (1894–1974), Maltese archaeologist
• Peter Baldacchino (born 1960), Maltese-born American Roman Catholic bishop
• Ruth Baldacchino, (born 1979), LGBT rights activist
• Ryan Baldacchino (born 1981), English footballer

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