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词条 Bath salts (drug)
释义

  1. History

  2. Pharmacology

  3. Usage

      Interaction with alcohol    Subjective effects  

  4. Health issues

  5. Detection

  6. Prevalence

  7. Legal status

  8. Society and the media

  9. See also

  10. References

{{Use American English|date=July 2018}}{{Use dmy dates|date=December 2013}}{{unfocused|date=August 2018}}

"Bath salts" (also "psychoactive bath salts", "PABS",[1][2] or in the United Kingdom monkey dust)[3] is a group of recreational designer drugs.[4][5] The name derives from instances in which the drugs were disguised as bath salts.[6][7][8] The white powder, granules, or crystals often resemble bath salts such as Epsom salts, but differ chemically. The drug's packaging often states "not for human consumption" in an attempt to circumvent drug prohibition laws.[6] Recreational drugs have also been disguised as plant food, hookah cleaner and other products.

History

Synthetic cathinones such as mephedrone, which are chemically similar to cathinone, naturally found in the plant Catha edulis (khat), were first synthesised in the 1920s.[8] They remained obscure until the first decade of the 21st century, when underground chemists rediscovered them and began to use them in designer drugs, as the compounds were legal in many jurisdictions.[8][9] In 2009 and 2010 there was a significant rise in the abuse of synthetic cathinones, initially in the United Kingdom and the rest of Europe, and subsequently in the United States. Drugs marketed as "bath salts" first came to the attention of authorities in the US in 2010 after reports were made to US poison centers.[7] In Europe, the drugs were predominantly purchased from websites, but in the US they were mainly sold in small independent stores such as gas stations and head shops.[7] In the US, this often made them easier to obtain than cigarettes and alcohol.[7] Bath salts have also been sold online in small packets.[10]

Hundreds of other designer drugs or "legal highs" have been reported, including artificial chemicals such as synthetic cannabis and semi-synthetic substances such as methylhexaneamine.[17] These drugs are primarily developed to avoid being controlled by laws against illegal drugs, thus giving them the label of designer drugs.[11]

In the US, the number of calls to poison centers concerning "bath salts" rose from 304 in 2010 to 6,138 in 2011, according to the American Association of Poison Control Centers.[10] Calls related to bath salts then began to decrease; by 2015, the number had declined to 522.[12]

Pharmacology

Pharmacologically, bath salts usually contain a cathinone, typically methylenedioxypyrovalerone (MDPV), methylone or mephedrone; however, the chemical composition varies widely[7][22] and products labeled with the same name may also contain derivatives of pyrovalerone or pipradrol. In Europe the main synthetic cathinone is mephedrone, whereas in the US MDPV is more common.[7]

Very little is known about how bath salts interact with the brain and how they are metabolised by the body. Scientists are inclined to believe that bath salts have a powerful addictive potential and can increase users' tolerance.[8][13] They are similar to amphetamines in that they cause stimulant effects by increasing the concentration of monoamines such as dopamine, serotonin, and norepinephrine in synapses.[8][14] They are generally less able to cross the blood brain barrier than amphetamines due to the presence of a beta-keto group that increases the compound's polarity.[8]

Usage

Bath salts can be orally ingested, snorted, smoked, or injected. Injection is especially ill-advised as these products rarely list ingredients, let alone dosage. Bath salts are detrimental to human health and can cause erratic behaviour, hallucinations, and delusions.[15]

Interaction with alcohol

Bath salts are often consumed concurrently with alcohol. A 2015 study[16] has investigated the interrelation between mephedrone and alcohol, focusing on psychostimulant and rewarding effects. It showed that alcohol, at low (non-stimulant) doses, significantly enhances the psychostimulant effects of mephedrone. This effect is mediated by an increase in synaptic dopamine, as haloperidol, but not ketanserin, was capable of blocking the potentiation by alcohol.{{fact|date=July 2018}}

Subjective effects

Bath Salts or Monkey Dust comes in a powdered or crystallised form which can be swallowed, smoked, injected or snorted. Subjective effects are similar to MDMA or cocaine but with a duration of 5–6 hours. Both substances cause a rapid onset of action in the central nervous system,[17] and stimulant toxicity. In larger doses this class of substances can cause effects similar to those seen in cases of serotonin syndrome.[18] Due to their rapid onset, synthetic cathinones are powerful reward/reinforcers, with high addiction potential.[19] "Monkey dust", "bath salts" or plant food are often used at the same time as classical psychoactive drugs. Users who have overdosed often display symptoms of; agitation, delirium, hallucinations, excessive motor activity, seizures, tachycardia, hypertension, and/or hyperthermia.[20]

Health issues

Bath salt users have reported symptoms that include headache, heart palpitations, nausea, cold fingers, hallucinations, paranoia, and panic attacks.[35] News media have reported reactions that include violent behavior,[21] heart attack, kidney failure, liver failure, suicide, an increased tolerance for pain,[6] dehydration, and breakdown of skeletal muscle tissue.[22]

Contrary to popular belief, investigators found no connection to bath salts in the Miami cannibal attack.[23]

Visual symptoms similar to those of stimulant overdoses include dilated pupils, involuntary muscle movement, rapid heartbeat, and high blood pressure.[24][25]

Detection

MDPV and other synthetic cathinones cannot be smelled by detection dogs[6] and are not detected by typical urinalysis,[26] though they can be detected in urine and hair using gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry.[27][28] Distributors may disguise the drug as everyday substances such as fertilizer or insect repellent.[6][29]

Prevalence

Little is known about how many people use bath salts.[8] In the UK, mephedrone, commonly known as MCAT, is the fourth most commonly used illicit drug among nightclub goers after cannabis, MDMA and cocaine.[8] Based on reports to the American Association of Poison Control Centers, use of bath salts in the US is thought to have increased significantly between 2010 and 2011.[8] The increase in use is thought to result from their widespread availability, undetectability on many drug tests, and sensationalist media coverage.[30]

Users tend to range from ages 15–55 with the average being age 28.[24]

Legal status

{{further information|Mephedrone#Legal status|Methylenedioxypyrovalerone#Legality|Methylone#Legal status}}

The drug policy of Canada since Fall 2012 categorizes methylenedioxypyrovalerone (MDPV) as a schedule I substance under the Controlled Drugs and Substances Act, placing it in the same category as heroin and MDMA.[6] Mephedrone and methylone are already illegal in Canada and most of the United States.[6]

In the United Kingdom, all substituted cathinones were made illegal in April 2010,[31][32] under the Misuse of Drugs Act 1971, but other designer drugs such as naphyrone appeared soon after[33] and some products described as legal contained illegal compounds.[34] To avoid being controlled by the Medicines Act, designer drugs such as mephedrone have been described as "bath salts", or other misnomers such as "plant food" despite the compounds having no history of being used for these purposes.[35][36][37]

In July 2012, US federal drug policy was amended to ban the drugs commonly found in bath salts.[38] Prior to that, bath salts were illegal in at least 41 states.[39] Prior to the compounds being made illegal, mephedrone, methylone, and MDPV were marketed as bath salts.[64] The "bath salt" name and labels that say "not for human consumption" are an attempt to skirt the Federal Analog Act, which forbids selling drugs that are substantially similar to drugs already classified for human use.[40][41][42]

Society and the media

Use of bath salts or monkey dust has spread through social media, although both are often misreported by the mainstream media.[43] Anecdotal reports of the drug lowering its users pain thresholds while simultaneously giving them increased strength can largely be attributed to the emergency services and frontline NHS staff. Such reports have been picked up, and sensationalised by the regional and tabloid press.[44][45] In the city Stoke-on-Trent,[46] Monkey Dust has been reported to be an entirely new compound, when in actual fact preparations of MDPV and MDPHP or "bath salts" have been available since the early 2000s.[47] The print press and broadcast media have often used textual framing techniques to report on synthetic cathinone use among societies most vulnerable. Terms like "epidemic", "zombie attack" and more recently "incredible hulk" are often used when describing users.[48] In August 2018, Staffordshire police said they were receiving around ten calls per day regarding Monkey Dust. However, it was not clear whether the incidents actually involved Monkey Dust, or a combination of substances.[49]

Bath Salts or Monkey dust were originally a research chemical or legal highs. Users would purchase the chemicals off the internet, ingest them and blog about the effects.[50]

See also

  • Illegal drug trade
  • Miami cannibal attack
  • Recreational drug use

References

1. ^{{cite journal|last1=Gray|first1=Bobbe Ann|last2=Holland|first2=Cindra|title=Implications of Psychoactive 'Bath Salts' Use During Pregnancy|journal=Nursing for Women's Health|date=June 2014|volume=18|issue=3|pages=220–30|doi=10.1111/1751-486X.12123|pmid=24939199}}
2. ^{{cite journal|last1=Ross|first1=Edward A.|last2=Watson|first2=Mary|last3=Goldberger|first3=Bruce|title="Bath Salts" Intoxication|journal=New England Journal of Medicine|date=8 September 2011|volume=365|issue=10|pages=967–8|doi=10.1056/NEJMc1107097}}
3. ^{{cite news |title=Monkey dust "epidemic" causing drug users to experience violent hallucinations |url=https://www.newsweek.com/what-monkey-dust-bath-salt-mpvd-drug-causing-epidemic-violent-hallucinations-1068295 |accessdate=17 August 2018 |work=Newsweek |date=10 August 2018 |language=en}}
4. ^{{cite web |url=http://www.justice.gov/dea/divisions/hq/2011/hq102111.shtml |title=DEA: Chemicals Used in "Bath Salts" Now Under Federal Control and Regulation |accessdate=28 December 2013}}
5. ^{{cite web |title=Situation Report. Synthetic Cathinones (Bath Salts): An Emerging Domestic Threat |url=http://www.justice.gov/archive/ndic/pubs44/44571/44571p.pdf |publisher=United States Department of Justice: National Drug Intelligence Center |accessdate=1 June 2013 }}
6. ^1 2 3 4 5 6 {{cite news |title=What are 'bath salts'? A look at Canada's newest illegal drug |url=http://www.cbc.ca/news/canada/what-are-bath-salts-a-look-at-canada-s-newest-illegal-drug-1.1143407 |date=25 June 2012 |last=Black |first=Matthew |publisher=Canadian Broadcasting Corporation |work=CBC News |accessdate=28 December 2013}}
7. ^1 2 3 4 5 {{Cite journal |vauthors=Spiller HA, Ryan ML, Weston RG, Jansen J | title = Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States | doi = 10.3109/15563650.2011.590812 | journal = Clinical Toxicology | volume = 49 | issue = 6 | pages = 499–505 | year = 2011 | pmid = 21824061| pmc = }}
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9. ^{{cite news |url=https://www.vice.com/read/hamilton-s-pharmacopeia-455-v17n6 |archiveurl=https://web.archive.org/web/20111030023436/http://www.vice.com/read/hamilton-s-pharmacopeia-455-v17n6 |archivedate=30 October 2011 |title=Hamilton’s Pharmacopeia. Mephedrone: the phantom menace |last=Morris |first=H. |publisher=Vice Magazine |date=5 April 2010 |deadurl=no}}
10. ^1 {{cite news |last=Dolak |first=Kevin |title='Bath Salts': Use of Dangerous Drug Increasing Across U.S. |url=http://abcnews.go.com/health/bath-salts-dangerous-drug-increasing-us/story?id=16496076 |publisher=ABC News: Good Morning America |date=5 June 2012 |accessdate=28 December 2013}} {{plays audio}}
11. ^1 {{cite journal |author=McElrath, K |author2=O'Neill, C |title=Experiences with mephedrone pre- and post-legislative controls: perceptions of safety and sources of supply |journal=The International Journal on Drug Policy |volume=22 |issue=2 |pages=120–7 |date=March 2011 |pmid=21242082 |doi=10.1016/j.drugpo.2010.11.001}}
12. ^{{cite web | url = http://www.aapcc.org/alerts/bath-salts | access-date = 18 January 2017 | title = Bath Salts | publisher = American Association of Poison Control Centers | quote = In 2012, poison centers took 2,697 calls about exposures to bath salts with the number reducing to 998 in 2013. In 2014, there were 587 exposure calls with the number reducing to 522 in 2015. | archive-url = https://web.archive.org/web/20170119053143/http://www.aapcc.org/alerts/bath-salts/ | archive-date = 19 January 2017 | dead-url = yes | df = dmy-all }}
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24. ^1 {{cite web |author=Miller, Michael C. |url=http://www.health.harvard.edu/newsletters/Harvard_Mental_Health_Letter/2011/September |title=Ask the Doctor: Bath salts—a new way to get high? |work=Harvard Mental Health Letter |date=September 2011 |quote=
Q. I heard a news story about people using bath salts to get high. How is that possible? My husband and I have two teenagers. Should we talk with them about this?

A. The "bath salts" you've heard about have nothing to do with the type that people add to water and use while soaking in a tub. These newer bath salts are designer drugs that circumvent the laws governing controlled or illegal substances, but can be used to get high.

The active chemicals in these salts — mephedrone, pyrovalerone, or methylenedioxypyrovalerone (MDPV) — all have stimulant properties. They are ... |accessdate=18 December 2013}} {{link note|note=contains additional text}}
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50. ^{{Cite news|url=https://www.theguardian.com/society/2014/jul/04/psychonauts-drugs-experiment-chemistry-legal-highs|title=Psychonauts explore unknown world of legal highs – with themselves as lab rats|last=Boseley|first=Sarah|date=2014-07-04|work=The Guardian|access-date=2019-02-08|last2=editor|first2=health|language=en-GB|issn=0261-3077}}
{{stimulants}}{{drug use|state=collapsed}}

2 : Drug culture|Drug policy
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