| 词条 | Binaltorphimine |
| 释义 |
| IUPAC_name = (1S,2S,7S,8R,12S,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-22-methyl-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.018,37.030,36]heptatriaconta-4(23),5(21),14(37),15,17,26(36),27,29-octaene-2,7,17,27-tetrol | image = Binaltorphimine.svg | width = 200px | CAS_number = 105618-27-7 | ATC_prefix = None | ATC_suffix = | PubChem = 5484197 | DrugBank = | ChemSpiderID = 24673307 | ChEMBL = 610001 | C=41 | H=45 | N=3 | O=6 | molecular_weight = 675.813 g/mol | smiles = CN1C2=C(C[C@]3([C@H]4CC5=C6[C@]3([C@H]2OC6=C(C=C5)O)CCN4CC7CC7)O)C8=C1[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1 | StdInChI = 1S/C41H45N3O6/c1-42-32-24(16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,36(32)49-34)10-12-43(28)18-20-2-3-20)25-17-41(48)29-15-23-7-9-27(46)35-31(23)39(41,37(50-35)33(25)42)11-13-44(29)19-21-4-5-21/h6-9,20-21,28-29,36-37,45-48H,2-5,10-19H2,1H3/t28-,29-,36+,37+,38+,39+,40-,41-/m1/s1 | StdInChIKey = DKIVQMBUHVYDFC-IWRYZOJTSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}Binaltorphimine (BNI) is a selective antagonist of the κ-opioid receptor (KOR).[1] BNI and norbinaltorphimine (nor-BNI) were the first highly selective KOR antagonists to be discovered.[1] See also
References1. ^1 {{cite journal |vauthors=Portoghese PS, Lipkowski AW, Takemori AE | title = Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists | journal = Life Sci. | volume = 40 | issue = 13 | pages = 1287–92 |date=March 1987 | pmid = 2882399 | doi = 10.1016/0024-3205(87)90585-6| url = }} {{Opioidergics}}{{nervous-system-drug-stub}} 4 : Morphinans|Phenols|Alcohols|Kappa antagonists |
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