| 词条 | BolA-like protein family |
| 释义 |
| Symbol = BolA | Name = BolA | image = PDB 1ny8 EBI.jpg | width = | caption = solution structure of protein yrba from escherichia coli: northeast structural genomics consortium target er115 | Pfam = PF01722 | Pfam_clan = | InterPro = IPR002634 | SMART = | PROSITE = | MEROPS = | SCOP = 1v9j | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the BolA-like protein family consists of the morpho-protein BolA from Escherichia coli, the Fra2 protein from Saccharomyces cerevisiae, and various homologs. The BolA protein is a DNA-binding regulator;[1] the Fra2 protein is an iron sulfur cluster protein that binds Grx3/4 and is involved in regulating iron levels .[2] In E. coli, over-expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division.[3] The expression of BolA is growth rate regulated and is induced during the transition into the stationary phase.[3] BolA is also induced by stress during early stages of growth [3] and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.[3][4] References1. ^{{cite journal |vauthors=Dressaire C, Moreira RN, Barahona S, Alves de Matos AP, Arraiano CM, Santos JM, Freire P, Vicente M, Arraiano CM | title = BolA Is a Transcriptional Switch That Turns Off Motility and Turns On Biofilm Development | journal = mBio | volume = 6 | issue = 1 | pages = e02352-14 | pmid = 25691594 | doi = 10.1128/mBio.02352-14| date = 17 February 2015 | pmc=4337573}} {{InterPro content|IPR002634}}2. ^{{cite journal |vauthors=Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE |title=The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation |journal=Biochemistry |volume=48 |issue=40 |pages=9569–81 |year=2009 |pmid=19715344 |pmc=2796373 |doi=10.1021/bi901182w }} 3. ^1 2 3 {{cite journal |vauthors=Santos JM, Freire P, Vicente M, Arraiano CM | title = The stationary-phase morphogene bolA from Escherichia coli is induced by stress during early stages of growth | journal = Mol. Microbiol. | volume = 32 | issue = 4 | pages = 789–98 |date=May 1999 | pmid = 10361282 | doi = 10.1046/j.1365-2958.1999.01397.x| url = }} 4. ^{{cite journal |vauthors=Aldea M, Garrido T, Hernandez-Chico C, Vicente M, Kushner SR | title = Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene | journal = EMBO J. | volume = 8 | issue = 12 | pages = 3923–31 |date=December 1989 | pmid = 2684651 | pmc = 402084 | doi = | url = }} 1 : Protein families |
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